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ENZYME entry: EC 1.5.8.3

Accepted Name
sarcosine dehydrogenase.
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]
Comment(s)
  • A flavoprotein (FMN) found in eukaryotes.
  • In the absence of tetrahydrofolate the enzyme produces formaldehyde. cf. EC 1.5.3.1 and EC 1.5.3.24.
  • Formerly EC 1.5.99.1.
Cross-references
BRENDA1.5.8.3
EC2PDB1.5.8.3
ExplorEnz1.5.8.3
PRIAM enzyme-specific profiles1.5.8.3
KEGG Ligand Database for Enzyme Nomenclature1.5.8.3
IUBMB Enzyme Nomenclature1.5.8.3
IntEnz1.5.8.3
MEDLINEFind literature relating to 1.5.8.3
MetaCyc1.5.8.3
Rhea expert-curated reactions1.5.8.3
UniProtKB/Swiss-Prot
Q9UL12, SARDH_HUMAN;  Q99LB7, SARDH_MOUSE;  Q64380, SARDH_RAT;  

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