ENZYME entry: EC 1.5.8.4
| Accepted Name |
|---|
| dimethylglycine dehydrogenase.
|
| Alternative Name(s) |
|---|
| Me2GlyDH. |
| Reaction catalysed |
|---|
| (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine |
| Comment(s) |
|---|
- An imine intermediate is channeled from the FAD binding site to the
5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel.
- In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms
formaldehyde.
- Formerly EC 1.5.99.2.
|
| Cross-references |
|---|
| BRENDA | 1.5.8.4 |
| EC2PDB | 1.5.8.4 |
| ExplorEnz | 1.5.8.4 |
| PRIAM enzyme-specific profiles | 1.5.8.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.5.8.4 |
| IUBMB Enzyme Nomenclature | 1.5.8.4 |
| IntEnz | 1.5.8.4 |
| MEDLINE | Find literature relating to 1.5.8.4 |
| MetaCyc | 1.5.8.4 |
| Rhea expert-curated reactions | 1.5.8.4 |
| UniProtKB/Swiss-Prot |
|
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