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ENZYME entry: EC 1.5.8.4

Accepted Name
dimethylglycine dehydrogenase.
Alternative Name(s)
Me2GlyDH.
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine
Comment(s)
  • An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel.
  • In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde.
  • Formerly EC 1.5.99.2.
Cross-references
BRENDA1.5.8.4
EC2PDB1.5.8.4
ExplorEnz1.5.8.4
PRIAM enzyme-specific profiles1.5.8.4
KEGG Ligand Database for Enzyme Nomenclature1.5.8.4
IUBMB Enzyme Nomenclature1.5.8.4
IntEnz1.5.8.4
MEDLINEFind literature relating to 1.5.8.4
MetaCyc1.5.8.4
Rhea expert-curated reactions1.5.8.4
UniProtKB/Swiss-Prot
Q9UI17, M2GD_HUMAN;  Q9DBT9, M2GD_MOUSE;  Q63342, M2GD_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-