ENZYME entry: EC 1.5.8.4
Accepted Name |
dimethylglycine dehydrogenase.
|
Alternative Name(s) |
Me2GlyDH. |
Reaction catalysed |
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine |
Comment(s) |
- An imine intermediate is channeled from the FAD binding site to the
5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel.
- In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms
formaldehyde.
- Formerly EC 1.5.99.2.
|
Cross-references |
BRENDA | 1.5.8.4 |
EC2PDB | 1.5.8.4 |
ExplorEnz | 1.5.8.4 |
PRIAM enzyme-specific profiles | 1.5.8.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.5.8.4 |
IUBMB Enzyme Nomenclature | 1.5.8.4 |
IntEnz | 1.5.8.4 |
MEDLINE | Find literature relating to 1.5.8.4 |
MetaCyc | 1.5.8.4 |
Rhea expert-curated reactions | 1.5.8.4 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.5.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-