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ENZYME

ENZYME entry: EC 1.6.3.1

Accepted Name
NAD(P)H oxidase (H2O2-forming)
Alternative Name(s)
dual oxidase
NAD(P)H oxidase
ThOX
THOX2
thyroid NADPH oxidase
thyroid oxidase
thyroid oxidase 2
Reaction catalysed
  • H(+) + NADPH + O2 = H2O2 + NADP(+)
  • H(+) + NADH + O2 = H2O2 + NAD(+)
Comment(s)
  • When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen.
  • The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups.
  • This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalyzed biosynthesis of thyroid hormones.
Cross-references
BRENDA1.6.3.1
EC2PDB1.6.3.1
ExplorEnz1.6.3.1
PRIAM enzyme-specific profiles1.6.3.1
KEGG Ligand Database for Enzyme Nomenclature1.6.3.1
IUBMB Enzyme Nomenclature1.6.3.1
IntEnz1.6.3.1
MEDLINEFind literature relating to 1.6.3.1
MetaCyc1.6.3.1
Rhea expert-curated reactions1.6.3.1
UniProtKB/Swiss-Prot
O61213, DUOX1_CAEELQ9MZF4, DUOX1_CANLFQ9NRD9, DUOX1_HUMAN
Q8HZK3, DUOX1_PIGQ8CIY2, DUOX1_RATQ9NRD8, DUOX2_HUMAN
Q8HZK2, DUOX2_PIGQ9ES45, DUOX2_RATQ9VQH2, DUOX_DROME
P49109, FMO5_CAVPOP49326, FMO5_HUMANP97872, FMO5_MOUSE
Q04799, FMO5_RABITQ8K4C0, FMO5_RATF1MH07, MICA1_BOVIN
E7F9T0, MICA1_DANREQ8TDZ2, MICA1_HUMANQ8VDP3, MICA1_MOUSE
D3ZBP4, MICA1_RATQ9NPH5, NOX4_HUMANQ9JHI8, NOX4_MOUSE
Q5R5C5, NOX4_PONABQ924V1, NOX4_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.3.-
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