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ENZYME

ENZYME entry: EC 1.6.3.5

PURL: https://purl.expasy.org/enzyme/EC/1.6.3.5
Accepted Name
renalase
Alternative Name(s)
alpha-NAD(P)H oxidase/anomerase
Reaction catalysed
  • 1,2-dihydro-beta-NAD + O2 + H(+) = H2O2 + NAD(+)
  • 1,2-dihydro-beta-NADP + O2 + H(+) = H2O2 + NADP(+)
  • 1,6-dihydro-beta-NAD + O2 + H(+) = H2O2 + NAD(+)
  • 1,6-dihydro-beta-NADP + O2 + H(+) = H2O2 + NADP(+)
Comment(s)
  • Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+).
  • These isomeric forms, generated by non-specific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
Cross-references
BRENDA1.6.3.5
EC2PDB1.6.3.5
ExplorEnz1.6.3.5
KEGG Ligand Database for Enzyme Nomenclature1.6.3.5
IUBMB Enzyme Nomenclature1.6.3.5
MEDLINEFind literature relating to 1.6.3.5
MetaCyc1.6.3.5
Rhea expert-curated reactions1.6.3.5
UniProtKB/Swiss-Prot
Q5VYX0, RNLS_HUMANA7RDN6, RNLS_MOUSEQ48MT7, RNLS_PSE14
Q888A4, RNLS_PSESMQ5U2W9, RNLS_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-