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ENZYME

ENZYME entry: EC 1.7.3.3

PURL: https://purl.expasy.org/enzyme/EC/1.7.3.3
Accepted Name
factor independent urate hydroxylase
Alternative Name(s)
urate oxidase
uric acid oxidase
uricase
uricase II
Reaction catalysed
urate + O2 + H2O = 5-hydroxyisourate + H2O2
Comment(s)
  • Was previously thought to be a copper protein, but it is now known that the enzymes from soybean (Glycine max), the mold Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion.
  • The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalyzed pathway in which EC 3.5.2.17 catalyzes the first step.
  • The enzyme is different from EC 1.14.13.113.
Cross-references
BRENDA1.7.3.3
EC2PDB1.7.3.3
ExplorEnz1.7.3.3
KEGG Ligand Database for Enzyme Nomenclature1.7.3.3
IUBMB Enzyme Nomenclature1.7.3.3
MEDLINEFind literature relating to 1.7.3.3
MetaCyc1.7.3.3
Rhea expert-curated reactions1.7.3.3
UniProtKB/Swiss-Prot
Q45697, PUCL_BACSBO32141, PUCL_BACSUP34798, URIC1_CANLI
P04670, URIC1_SOYBNP34799, URIC2_CANLIO04104, URIC2_SOYBN
Q8MKJ2, URIC_AOTTRO04420, URIC_ARATHD0VWQ1, URIC_ARTGO
Q00511, URIC_ASPFLQ3MHG7, URIC_BOVINQ5FZI9, URIC_CANLF
P78609, URIC_CYBJAQ6DG85, URIC_DANREQ54LT2, URIC_DICDI
P16163, URIC_DROMEP22673, URIC_DROPSO44111, URIC_DROSU
P23194, URIC_DROVIP33282, URIC_EMENID8JBB7, URIC_HALJB
D4GPU7, URIC_HALVDQ8MHW6, URIC_MACFAQ8MKJ3, URIC_MACMU
P25688, URIC_MOUSEP25689, URIC_PAPHAP53763, URIC_PHAVU
P16164, URIC_PIGP82858, URIC_PUCREP11645, URIC_RABIT
P09118, URIC_RATO74409, URIC_SCHPO

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