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ENZYME entry: EC 1.7.3.3

Accepted Name
Factor independent urate hydroxylase.
Alternative Name(s)
Urate oxidase.
Uric acid oxidase.
Uricase.
Uricase II.
Reaction catalysed
Urate + O(2) + H(2)O <=> 5-hydroxyisourate + H(2)O(2)
Comment(s)
  • Was previously thought to be a copper protein, but it is now known that the enzymes from soybean (Glycine max), the mold Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion.
  • The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO(2), although there is an enzyme-catalyzed pathway in which EC 3.5.2.17 catalyzes the first step.
  • The enzyme is different from EC 1.14.13.113.
Cross-references
PROSITEPDOC00315
BRENDA1.7.3.3
EC2PDB1.7.3.3
ExplorEnz1.7.3.3
PRIAM enzyme-specific profiles1.7.3.3
KEGG Ligand Database for Enzyme Nomenclature1.7.3.3
IUBMB Enzyme Nomenclature1.7.3.3
IntEnz1.7.3.3
MEDLINEFind literature relating to 1.7.3.3
MetaCyc1.7.3.3
Rhea expert-curated reactions1.7.3.3
UniProtKB/Swiss-Prot
Q45697, PUCL_BACSB;  O32141, PUCL_BACSU;  P34798, URIC1_CANLI;  
P04670, URIC1_SOYBN;  P34799, URIC2_CANLI;  O04104, URIC2_SOYBN;  
Q8MKJ2, URIC_AOTTR;  O04420, URIC_ARATH;  D0VWQ1, URIC_ARTGO;  
Q00511, URIC_ASPFL;  Q3MHG7, URIC_BOVIN;  Q5FZI9, URIC_CANLF;  
P78609, URIC_CYBJA;  Q6DG85, URIC_DANRE;  Q54LT2, URIC_DICDI;  
P16163, URIC_DROME;  P22673, URIC_DROPS;  O44111, URIC_DROSU;  
P23194, URIC_DROVI;  P33282, URIC_EMENI;  D8JBB7, URIC_HALJB;  
D4GPU7, URIC_HALVD;  Q8MHW6, URIC_MACFA;  Q8MKJ3, URIC_MACMU;  
P25688, URIC_MOUSE;  P25689, URIC_PAPHA;  P53763, URIC_PHAVU;  
P16164, URIC_PIG;  P82858, URIC_PUCRE;  P11645, URIC_RABIT;  
P09118, URIC_RAT;  O74409, URIC_SCHPO;  

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