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ENZYME entry: EC 1.7.3.3
Accepted Name |
factor independent urate hydroxylase.
|
Alternative Name(s) |
urate oxidase. |
uric acid oxidase. |
uricase. |
uricase II. |
Reaction catalysed |
H2O + O2 + urate <=> 5-hydroxyisourate + H2O2 |
Comment(s) |
- Was previously thought to be a copper protein, but it is now known
that the enzymes from soybean (Glycine max), the mold Aspergillus
flavus and Bacillus subtilis contains no copper nor any other
transition-metal ion.
- The 5-hydroxyisourate formed decomposes spontaneously to form
allantoin and CO2, although there is an enzyme-catalyzed pathway in
which EC 3.5.2.17 catalyzes the first step.
- The enzyme is different from EC 1.14.13.113.
|
Cross-references |
BRENDA | 1.7.3.3 |
EC2PDB | 1.7.3.3 |
ExplorEnz | 1.7.3.3 |
PRIAM enzyme-specific profiles | 1.7.3.3 |
KEGG Ligand Database for Enzyme Nomenclature | 1.7.3.3 |
IUBMB Enzyme Nomenclature | 1.7.3.3 |
IntEnz | 1.7.3.3 |
MEDLINE | Find literature relating to 1.7.3.3 |
MetaCyc | 1.7.3.3 |
Rhea expert-curated reactions | 1.7.3.3 |
UniProtKB/Swiss-Prot |
Q45697, PUCL_BACSB; | O32141, PUCL_BACSU; | P34798, URIC1_CANLI; |
P04670, URIC1_SOYBN; | P34799, URIC2_CANLI; | O04104, URIC2_SOYBN; |
Q8MKJ2, URIC_AOTTR; | O04420, URIC_ARATH; | D0VWQ1, URIC_ARTGO; |
Q00511, URIC_ASPFL; | Q3MHG7, URIC_BOVIN; | Q5FZI9, URIC_CANLF; |
P78609, URIC_CYBJA; | Q6DG85, URIC_DANRE; | Q54LT2, URIC_DICDI; |
P16163, URIC_DROME; | P22673, URIC_DROPS; | O44111, URIC_DROSU; |
P23194, URIC_DROVI; | P33282, URIC_EMENI; | D8JBB7, URIC_HALJB; |
D4GPU7, URIC_HALVD; | Q8MHW6, URIC_MACFA; | Q8MKJ3, URIC_MACMU; |
P25688, URIC_MOUSE; | P25689, URIC_PAPHA; | P53763, URIC_PHAVU; |
P16164, URIC_PIG; | P82858, URIC_PUCRE; | P11645, URIC_RABIT; |
P09118, URIC_RAT; | O74409, URIC_SCHPO; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.7.3.-
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