A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.8.99.5
| Accepted Name |
|---|
| Dissimilatory sulfite reductase.
|
| Alternative Name(s) |
|---|
| Siroheme sulfite reductase. |
| Reaction catalysed |
|---|
- Hydrogen sulfide + a [DsrC protein]-disulfide + 2 acceptor + 3 H(2)O <=> sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H(+)
- A [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H(2)O <=> sulfite + a [DsrC protein]-disulfide + 3 reduced acceptor + 2 H(+)
|
| Cofactor(s) |
|---|
| Siroheme.
|
| Comment(s) |
|---|
- The enzyme is essential in prokaryotic sulfur-based energy
metabolism, including sulfate/sulfite reducing organisms, sulfur-
oxidizing bacteria, and organosulfonate reducers.
- In sulfur reducers it catalyzes the reduction of sulfite to sulfide,
while in sulfur oxidizers it catalyzes the opposite reaction.
- The reaction involves the small protein DsrC, which is present in all
the organisms that contain dissimilatory sulfite reductase.
- During the process an intramolecular disulfide bond is formed between
two L-cysteine residues of DsrC.
- This disulfide can be reduced by a number of proteins including DsrK
and TcmB.
- This enzyme is different from EC 1.8.1.2 and EC 1.8.7.1, which are
involved in sulfate assimilation.
|
| Cross-references |
|---|
| BRENDA | 1.8.99.5 |
| EC2PDB | 1.8.99.5 |
| ExplorEnz | 1.8.99.5 |
| PRIAM enzyme-specific profiles | 1.8.99.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.8.99.5 |
| IUBMB Enzyme Nomenclature | 1.8.99.5 |
| IntEnz | 1.8.99.5 |
| MEDLINE | Find literature relating to 1.8.99.5 |
| MetaCyc | 1.8.99.5 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.8.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-