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ENZYME entry: EC

Accepted Name
dissimilatory sulfite reductase
Alternative Name(s)
siroheme sulfite reductase
Reaction catalysed
  • [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite
  • [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite
  • The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur- oxidizing bacteria, and organosulfonate reducers.
  • In sulfur reducers it catalyzes the reduction of sulfite to sulfide, while in sulfur oxidizers it catalyzes the opposite reaction.
  • The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase.
  • During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC.
  • This disulfide can be reduced by a number of proteins including DsrK and TcmB.
  • This enzyme is different from EC and EC, which are involved in sulfate assimilation.
  • Formerly EC
PRIAM enzyme-specific profiles1.8.99.5
KEGG Ligand Database for Enzyme Nomenclature1.8.99.5
IUBMB Enzyme Nomenclature1.8.99.5
MEDLINEFind literature relating to
Rhea expert-curated reactions1.8.99.5

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