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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.8.99.5

Accepted Name
Dissimilatory sulfite reductase.
Alternative Name(s)
Siroheme sulfite reductase.
Reaction catalysed
  • Hydrogen sulfide + a [DsrC protein]-disulfide + 2 acceptor + 3 H(2)O <=> sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H(+)
  • A [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H(2)O <=> sulfite + a [DsrC protein]-disulfide + 3 reduced acceptor + 2 H(+)
Cofactor(s)
Siroheme.
Comment(s)
  • The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur- oxidizing bacteria, and organosulfonate reducers.
  • In sulfur reducers it catalyzes the reduction of sulfite to sulfide, while in sulfur oxidizers it catalyzes the opposite reaction.
  • The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase.
  • During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC.
  • This disulfide can be reduced by a number of proteins including DsrK and TcmB.
  • This enzyme is different from EC 1.8.1.2 and EC 1.8.7.1, which are involved in sulfate assimilation.
Cross-references
BRENDA1.8.99.5
EC2PDB1.8.99.5
ExplorEnz1.8.99.5
PRIAM enzyme-specific profiles1.8.99.5
KEGG Ligand Database for Enzyme Nomenclature1.8.99.5
IUBMB Enzyme Nomenclature1.8.99.5
IntEnz1.8.99.5
MEDLINEFind literature relating to 1.8.99.5
MetaCyc1.8.99.5
UniProtKB/Swiss-Prot
O33998, DSRA_ALLVD;  Q59109, DSRA_ARCFU;  Q59110, DSRB_ARCFU;  
P94694, DSVB_DESGG;  P45575, DSVB_DESVH;  P45573, DSVC_DESVH;  

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