ENZYME entry: EC 2.1.1.114
Accepted Name |
Polyprenyldihydroxybenzoate methyltransferase.
|
Alternative Name(s) |
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase. |
DHHB methyltransferase. |
DHHB O-methyltransferase. |
DHHB-Mt. |
Dihydroxyhexaprenylbenzoate methyltransferase. |
Reaction catalysed |
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate <=> S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate |
Comment(s) |
- This enzyme is involved in ubiquinone biosynthesis.
- Ubiquinones from different organisms have a different number of
prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-
9 in rat and ubiquinone-10 in human), and thus the natural substrate
for the enzymes from different organisms has a different number of
prenyl units.
- However, the enzyme usually shows a low degree of specificity
regarding the number of prenyl units.
- For example, the human COQ3 enzyme can restore biosynthesis of
ubiquinone-6 in coq3 deletion mutants of yeast.
- The enzymes from yeast and rat also catalyze the methylation of
3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this
activity is classified as EC 2.1.1.64).
|
Cross-references |
BRENDA | 2.1.1.114 |
EC2PDB | 2.1.1.114 |
ExplorEnz | 2.1.1.114 |
PRIAM enzyme-specific profiles | 2.1.1.114 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.114 |
IUBMB Enzyme Nomenclature | 2.1.1.114 |
IntEnz | 2.1.1.114 |
MEDLINE | Find literature relating to 2.1.1.114 |
MetaCyc | 2.1.1.114 |
Rhea expert-curated reactions | 2.1.1.114 |
UniProtKB/Swiss-Prot |
|
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