A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.1.1.114
| Accepted Name |
|---|
| Polyprenyldihydroxybenzoate methyltransferase.
|
| Alternative Name(s) |
|---|
| 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase. |
| DHHB methyltransferase. |
| DHHB O-methyltransferase. |
| DHHB-Mt. |
| Dihydroxyhexaprenylbenzoate methyltransferase. |
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate <=> S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate |
| Comment(s) |
|---|
- This enzyme is involved in ubiquinone biosynthesis.
- Ubiquinones from different organisms have a different number of
prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-
9 in rat and ubiquinone-10 in human), and thus the natural substrate
for the enzymes from different organisms has a different number of
prenyl units.
- However, the enzyme usually shows a low degree of specificity
regarding the number of prenyl units.
- For example, the human COQ3 enzyme can restore biosynthesis of
ubiquinone-6 in coq3 deletion mutants of yeast.
- The enzymes from yeast and rat also catalyze the methylation of
3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this
activity is classified as EC 2.1.1.64).
|
| Cross-references |
|---|
| BRENDA | 2.1.1.114 |
| EC2PDB | 2.1.1.114 |
| ExplorEnz | 2.1.1.114 |
| PRIAM enzyme-specific profiles | 2.1.1.114 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.114 |
| IUBMB Enzyme Nomenclature | 2.1.1.114 |
| IntEnz | 2.1.1.114 |
| MEDLINE | Find literature relating to 2.1.1.114 |
| MetaCyc | 2.1.1.114 |
| UniProtKB/Swiss-Prot |
|
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