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ENZYME

ENZYME entry: EC 2.1.1.114

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.114
Accepted Name
polyprenyldihydroxybenzoate methyltransferase
Alternative Name(s)
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
DHHB methyltransferase
DHHB-Mt
DHHB O-methyltransferase
dihydroxyhexaprenylbenzoate methyltransferase
Reaction catalysed
a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • This enzyme is involved in ubiquinone biosynthesis.
  • Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.
  • However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
  • For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast.
  • The enzymes from yeast and rat also catalyze the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively (this activity is classified as EC 2.1.1.64).
Cross-references
BRENDA2.1.1.114
EC2PDB2.1.1.114
ExplorEnz2.1.1.114
KEGG Ligand Database for Enzyme Nomenclature2.1.1.114
IUBMB Enzyme Nomenclature2.1.1.114
MEDLINEFind literature relating to 2.1.1.114
MetaCyc2.1.1.114
Rhea expert-curated reactions2.1.1.114
UniProtKB/Swiss-Prot
O49354, COQ3_ARATHQ3T131, COQ3_BOVINO93995, COQ3_CANAX
Q54XD0, COQ3_DICDIQ9NZJ6, COQ3_HUMANQ8BMS4, COQ3_MOUSE
Q63159, COQ3_RATO74421, COQ3_SCHPOP27680, COQ3_YEAST

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