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ENZYME

ENZYME entry: EC 2.1.1.64

Accepted Name
3-demethylubiquinol 3-O-methyltransferase
Alternative Name(s)
2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase
3-demethylubiquinone-9 3-methyltransferase
5-demethylubiquinone-9 methyltransferase
Reaction catalysed
a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • This enzyme is involved in ubiquinone biosynthesis.
  • Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.
  • However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
  • For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast.
  • The enzymes from yeast, Escherichia coli and rat also catalyze the methylation of 3,4-dihydroxy-5-all-trans-polyprenylbenzoate (a reaction that is classified as EC 2.1.1.114).
Cross-references
BRENDA2.1.1.64
EC2PDB2.1.1.64
ExplorEnz2.1.1.64
PRIAM enzyme-specific profiles2.1.1.64
KEGG Ligand Database for Enzyme Nomenclature2.1.1.64
IUBMB Enzyme Nomenclature2.1.1.64
IntEnz2.1.1.64
MEDLINEFind literature relating to 2.1.1.64
MetaCyc2.1.1.64
Rhea expert-curated reactions2.1.1.64
UniProtKB/Swiss-Prot
O49354, COQ3_ARATHQ3T131, COQ3_BOVINO93995, COQ3_CANAX
Q54XD0, COQ3_DICDIQ9NZJ6, COQ3_HUMANQ8BMS4, COQ3_MOUSE
Q63159, COQ3_RATO74421, COQ3_SCHPOP27680, COQ3_YEAST
A1TSA0, UBIG_ACIACQ6FFY1, UBIG_ACIADB7H2Y9, UBIG_ACIB3
B7IBN2, UBIG_ACIB5B2I023, UBIG_ACIBCB0VMN8, UBIG_ACIBS
B0V5X4, UBIG_ACIBYA3MZ07, UBIG_ACTP2B3H0C8, UBIG_ACTP7
A4SM99, UBIG_AERS4Q8UA66, UBIG_AGRFCB9JB78, UBIG_AGRRK
Q21UL3, UBIG_ALBFTQ5E5J8, UBIG_ALIF1B5FDT8, UBIG_ALIFM
Q0AA73, UBIG_ALKEHQ5P7U3, UBIG_AROAEA8HVC4, UBIG_AZOC5
A1K8Q1, UBIG_AZOSBC1DRQ3, UBIG_AZOVDA1URT5, UBIG_BARBK
Q6G5K3, UBIG_BARHEQ6G0I1, UBIG_BARQUA9IQF4, UBIG_BART1
Q2L2T5, UBIG_BORA1Q7WGT9, UBIG_BORBRQ7W5Z6, UBIG_BORPA
Q7VZG7, UBIG_BORPEQ89XU2, UBIG_BRADUA4YKT6, UBIG_BRASO
B2S828, UBIG_BRUA1Q2YLN5, UBIG_BRUA2A6WXQ0, UBIG_BRUA4
A9M8K8, UBIG_BRUC2C0RFB8, UBIG_BRUMBQ8YJ98, UBIG_BRUME
A5VSK3, UBIG_BRUO2B0CIC6, UBIG_BRUSIQ8FYK0, UBIG_BRUSU
B1YV26, UBIG_BURA4A0K5L4, UBIG_BURCHB4EB49, UBIG_BURCJ
Q0BHA0, UBIG_BURCMQ39IG8, UBIG_BURL3A9ADW3, UBIG_BURM1
Q62M18, UBIG_BURMAB1JXR2, UBIG_BURO0Q1BY35, UBIG_BURO1
Q3JPX1, UBIG_BURP1Q63RZ8, UBIG_BURPSQ2SY32, UBIG_BURTA
A4JCG7, UBIG_BURVGB0SW81, UBIG_CAUSKQ9A9X1, UBIG_CAUVC
B8H209, UBIG_CAUVNA3PNM3, UBIG_CERS1Q3IYM5, UBIG_CERS4
A4WW91, UBIG_CERS5B9KPP7, UBIG_CERSKQ11E01, UBIG_CHESB
Q7NZ91, UBIG_CHRVOA8ADY5, UBIG_CITK8Q482G8, UBIG_COLP3
B6J5Y2, UBIG_COXB1B6J1W2, UBIG_COXB2A9KGL7, UBIG_COXBN
A9NBI0, UBIG_COXBRQ820B5, UBIG_COXBUA7MPA9, UBIG_CROS8
Q46Y42, UBIG_CUPPJQ47GP8, UBIG_DECARA8LQ43, UBIG_DINSH
A7ZP50, UBIG_ECO24B7UFP4, UBIG_ECO27B7MFZ8, UBIG_ECO45
B7LAP9, UBIG_ECO55Q8XE29, UBIG_ECO57B5YX17, UBIG_ECO5E
B7NN47, UBIG_ECO7IB7MXR3, UBIG_ECO81B7M5R7, UBIG_ECO8A
C4ZU73, UBIG_ECOBWB1X8C6, UBIG_ECODHA8A296, UBIG_ECOHS
Q0TFL0, UBIG_ECOL5Q8FFP0, UBIG_ECOL6B1IXV6, UBIG_ECOLC
P17993, UBIG_ECOLIB7N5J4, UBIG_ECOLUB6I7I7, UBIG_ECOSE
B1LLI3, UBIG_ECOSMQ1R9I4, UBIG_ECOUTA4WCN5, UBIG_ENT38
B2VIL6, UBIG_ERWT9B7LM95, UBIG_ESCF3B8F4B1, UBIG_GLAP5
Q7VKW2, UBIG_HAEDUQ0I3Y4, UBIG_HAES1Q2SE61, UBIG_HAHCH
B0UUV6, UBIG_HISS2Q31GD8, UBIG_HYDCUQ5QZ53, UBIG_IDILO
Q28VP7, UBIG_JANSCB5XNZ3, UBIG_KLEP3A6TBT7, UBIG_KLEP7
B1Y2L3, UBIG_LEPCPQ2W6W0, UBIG_MAGSAQ0AME1, UBIG_MARMM
A1U3K1, UBIG_MARN8Q609G2, UBIG_METCAB8IUB0, UBIG_METNO
B0UAV0, UBIG_METS4B8EI29, UBIG_METSBA9M0C4, UBIG_NEIM0
Q9JWE6, UBIG_NEIMAQ9JXI7, UBIG_NEIMBQ81ZZ2, UBIG_NITEU
Q2Y6Z3, UBIG_NITMUQ3J8U2, UBIG_NITOCQ3SVP3, UBIG_NITWN
A7HTX8, UBIG_PARL1B2JEZ6, UBIG_PARP8B2T641, UBIG_PARPJ
Q13VB4, UBIG_PARXLQ9CMI6, UBIG_PASMUQ6D7X5, UBIG_PECAS
C6DBN5, UBIG_PECCPQ4FNA2, UBIG_PELUBQ7N2M5, UBIG_PHOLL
Q6LPD7, UBIG_PHOPRB4EZ30, UBIG_PROMHQ48FM4, UBIG_PSE14
A6V2Q4, UBIG_PSEA7B7V9J5, UBIG_PSEA8Q02PX7, UBIG_PSEAB
Q9HZ63, UBIG_PSEAEQ1IDA6, UBIG_PSEE4Q4K8M4, UBIG_PSEF5
C3K6J1, UBIG_PSEFSA5W7G3, UBIG_PSEP1Q3K8T6, UBIG_PSEPF
B0KTX4, UBIG_PSEPGQ88M10, UBIG_PSEPKB1J5G4, UBIG_PSEPW
Q885T9, UBIG_PSESMQ3ILA5, UBIG_PSET1Q4ZQ90, UBIG_PSEU2
A4VLX7, UBIG_PSEU5Q4FVG3, UBIG_PSYA2Q1QEI9, UBIG_PSYCK
Q8Y0Z5, UBIG_RALSOB3PP83, UBIG_RHIE6Q2K3S8, UBIG_RHIEC
Q1MBA9, UBIG_RHIL3Q98G87, UBIG_RHILOB5ZRR7, UBIG_RHILW
Q92MK1, UBIG_RHIMEQ2J419, UBIG_RHOP2Q07VB6, UBIG_RHOP5
Q6NC69, UBIG_RHOPAQ21BZ6, UBIG_RHOPBQ13EZ9, UBIG_RHOPS
B3QCF3, UBIG_RHOPTQ2RWE9, UBIG_RHORTA8GPB1, UBIG_RICAH
A8GX11, UBIG_RICB8Q1RJC7, UBIG_RICBRA8EY40, UBIG_RICCK
Q92H07, UBIG_RICCNQ4UME7, UBIG_RICFEQ9ZCT9, UBIG_RICPR
Q68WB5, UBIG_RICTYQ16D32, UBIG_ROSDOQ5LWM6, UBIG_RUEPO
Q1GCH8, UBIG_RUESTQ21IR9, UBIG_SACD2B5EYW1, UBIG_SALA4
A9MJY3, UBIG_SALARQ57M77, UBIG_SALCHB5FNR7, UBIG_SALDC
B5R249, UBIG_SALEPB5RCA1, UBIG_SALG2B4TBE3, UBIG_SALHS
B4SYU8, UBIG_SALNSQ5PCY1, UBIG_SALPAC0Q093, UBIG_SALPC
B5BCS0, UBIG_SALPKB4TPG0, UBIG_SALSVQ8Z560, UBIG_SALTI
P37431, UBIG_SALTYA8GGX8, UBIG_SERP5A1S6C9, UBIG_SHEAM
B8EA88, UBIG_SHEB2A3D499, UBIG_SHEB5A6WNN7, UBIG_SHEB8
A9L2Y4, UBIG_SHEB9B0TT38, UBIG_SHEHHQ8EEG9, UBIG_SHEON
A8H499, UBIG_SHEPAA4Y759, UBIG_SHEPCA0KWN3, UBIG_SHESA
Q0HIX5, UBIG_SHESMQ0HV07, UBIG_SHESRA1RJD1, UBIG_SHESW
B2TW20, UBIG_SHIB3Q31Z65, UBIG_SHIBSQ32DV8, UBIG_SHIDS
Q0T2P9, UBIG_SHIF8Q820C5, UBIG_SHIFLQ3YZX6, UBIG_SHISS
C3MHQ9, UBIG_SINFNA6UCF6, UBIG_SINMWQ2NSL7, UBIG_SODGM
Q3SK91, UBIG_THIDAB7VGS0, UBIG_VIBA3A7MU79, UBIG_VIBC1
A5F1U0, UBIG_VIBC3Q9KSJ9, UBIG_VIBCHC3LLV3, UBIG_VIBCM
Q87ND5, UBIG_VIBPAQ8D8E0, UBIG_VIBVUQ7MM27, UBIG_VIBVY
Q8PK00, UBIG_XANACQ3BSF8, UBIG_XANC5Q4UVL4, UBIG_XANC8
B0RS27, UBIG_XANCBQ8P8H2, UBIG_XANCPQ2P2C4, UBIG_XANOM
B2SHS9, UBIG_XANOPQ5GZB5, UBIG_XANORB2I705, UBIG_XYLF2
Q9PAM5, UBIG_XYLFAB0U3W1, UBIG_XYLFMQ87BG5, UBIG_XYLFT
A1JLA0, UBIG_YERE8A7FKF4, UBIG_YERP3Q1C9H5, UBIG_YERPA
B2K9A4, UBIG_YERPBQ8ZGR6, UBIG_YERPEA9R284, UBIG_YERPG
Q1CFZ1, UBIG_YERPNA4TNI8, UBIG_YERPPQ66CZ4, UBIG_YERPS
B1JS96, UBIG_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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