| Accepted Name |
|---|
| Methionine synthase.
|
| Alternative Name(s) |
|---|
| 5-methyltetrahydrofolate--homocysteine S-methyltransferase. |
| 5-methyltetrahydrofolate--homocysteine transmethylase. |
| B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase. |
| Cobalamin-dependent methionine synthase. |
| Methionine synthase (cobalamin-dependent). |
| Methionine synthetase. |
| Methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase. |
| N(5)-methyltetrahydrofolate methyltransferase. |
| N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase. |
| N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase. |
| N-methyltetrahydrofolate:L-homocysteine methyltransferase. |
| Tetrahydrofolate methyltransferase. |
| Tetrahydropteroylglutamate methyltransferase. |
| Tetrahydropteroylglutamic methyltransferase. |
| Vitamin B12 methyltransferase. |
| Reaction catalysed |
|---|
| 5-methyltetrahydrofolate + L-homocysteine <=> tetrahydrofolate + L-methionine |
| Cofactor(s) |
|---|
| Cob(II)alamin; Zn(2+).
|
| Comment(s) |
|---|
- The enzyme becomes inactivated occasionally during its cycle by
oxidation of Co(I) to Co(II).
- Reactivation by reductive methylation is catalyzed by the enzyme
itself, with S-adenosyl-L-methionine as the methyl donor and a
reducing system.
- For the mammalian enzyme, the reducing system involves NADPH and
EC 1.16.1.8.
- In bacteria, the reducing agent is flavodoxin, and no further
catalyst is needed (the flavodoxin is kept in the reduced state by
NADPH and EC 1.18.1.2).
- Acts on the monoglutamate as well as the triglutamate folate,
in contrast with EC 2.1.1.14, which acts only on the triglutamate.
|
| Cross-references |
|---|
| PROSITE | PDOC50972 |
| BRENDA | 2.1.1.13 |
| EC2PDB | 2.1.1.13 |
| ExplorEnz | 2.1.1.13 |
| PRIAM enzyme-specific profiles | 2.1.1.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.13 |
| IUBMB Enzyme Nomenclature | 2.1.1.13 |
| IntEnz | 2.1.1.13 |
| MEDLINE | Find literature relating to 2.1.1.13 |
| MetaCyc | 2.1.1.13 |
| Rhea expert-curated reactions | 2.1.1.13 |
| UniProtKB/Swiss-Prot |
| Q5E814, METH_ALIF1; | Q9AJQ8, METH_ALIFS; | Q4JIJ3, METH_BOVIN; |
| A8XY95, METH_CAEBR; | Q09582, METH_CAEEL; | Q54P92, METH_DICDI; |
| P13009, METH_ECOLI; | Q99707, METH_HUMAN; | A6H5Y3, METH_MOUSE; |
| Q49775, METH_MYCLE; | O33259, METH_MYCTU; | Q9I2Q2, METH_PSEAE; |
| O33465, METH_PSEPU; | Q9Z2Q4, METH_RAT; | P37586, METH_SALTY; |
| Q55786, METH_SYNY3; | Q9KUW9, METH_VIBCH; | Q87L95, METH_VIBPA; |
| Q8DCJ7, METH_VIBVU; | Q7MHB1, METH_VIBVY; |
|