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ENZYME entry: EC 2.1.1.131

Accepted Name
Precorrin-3B C(17)-methyltransferase.
Alternative Name(s)
Precorrin-3 methylase.
Precorrin-3 methyltransferase.
Precorrin-3B C17-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + precorrin-3B <=> S-adenosyl-L-homocysteine + precorrin-4
Comment(s)
  • The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyzes a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17.
  • See EC 2.1.1.272 for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
Cross-references
BRENDA2.1.1.131
EC2PDB2.1.1.131
ExplorEnz2.1.1.131
PRIAM enzyme-specific profiles2.1.1.131
KEGG Ligand Database for Enzyme Nomenclature2.1.1.131
IUBMB Enzyme Nomenclature2.1.1.131
IntEnz2.1.1.131
MEDLINEFind literature relating to 2.1.1.131
MetaCyc2.1.1.131
Rhea expert-curated reactions2.1.1.131
UniProtKB/Swiss-Prot
P66878, COBIJ_MYCBO;  P9WGB2, COBIJ_MYCTO;  P9WGB3, COBIJ_MYCTU;  
P21640, COBJ_SINSX;  

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