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ENZYME

ENZYME entry: EC 2.1.1.131

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.131
Accepted Name
precorrin-3B C(17)-methyltransferase
Alternative Name(s)
precorrin-3B C17-methyltransferase
precorrin-3 methylase
precorrin-3 methyltransferase
Reaction catalysed
precorrin-3B + S-adenosyl-L-methionine = precorrin-4 + S-adenosyl-L-homocysteine + 3 H(+)
Comment(s)
  • The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyzes a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17.
  • See EC 2.1.1.272 for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
Cross-references
Rhea expert-curated reactions2.1.1.131
ExplorEnz2.1.1.131
IUBMB Enzyme Nomenclature2.1.1.131
UniProtKB/Swiss-Prot
P66878, COBIJ_MYCBOP9WGB2, COBIJ_MYCTOP9WGB3, COBIJ_MYCTU
P21640, COBJ_SINSX
BRENDA2.1.1.131
MetaCyc2.1.1.131
KEGG Ligand Database for Enzyme Nomenclature2.1.1.131
EC2PDB2.1.1.131
MEDLINEFind literature relating to 2.1.1.131

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