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ENZYME entry: EC 2.1.1.272

Accepted Name
Cobalt-factor III methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + cobalt-factor III + reduced acceptor <=> S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor
Comment(s)
  • Isolated from Bacillus megaterium.
  • The enzyme catalyzes both methylation at C-17 and ring contraction.
  • Contains a [4Fe-4S] cluster.
  • It can also convert cobalt-precorrin-3 to cobalt-precorrin-4.
  • The reductant may be thioredoxin.
Cross-references
BRENDA2.1.1.272
EC2PDB2.1.1.272
ExplorEnz2.1.1.272
PRIAM enzyme-specific profiles2.1.1.272
KEGG Ligand Database for Enzyme Nomenclature2.1.1.272
IUBMB Enzyme Nomenclature2.1.1.272
IntEnz2.1.1.272
MEDLINEFind literature relating to 2.1.1.272
MetaCyc2.1.1.272
UniProtKB/Swiss-Prot
O87689, CBIH_BACME

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