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ENZYME entry: EC 2.1.1.272

Accepted Name
Cobalt-factor III methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + cobalt-factor III + reduced acceptor <=> S-adenosyl-L-homocysteine + cobalt-precorrin-4 + acceptor
Comment(s)
  • Isolated from the bacterium Bacillus megaterium.
  • The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyzes a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17.
  • Contains a [4Fe-4S] cluster.
  • It can also convert cobalt-precorrin-3 to cobalt-precorrin-4.
  • The reductant may be thioredoxin.
  • See EC 2.1.1.131 for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.
Cross-references
BRENDA2.1.1.272
EC2PDB2.1.1.272
ExplorEnz2.1.1.272
PRIAM enzyme-specific profiles2.1.1.272
KEGG Ligand Database for Enzyme Nomenclature2.1.1.272
IUBMB Enzyme Nomenclature2.1.1.272
IntEnz2.1.1.272
MEDLINEFind literature relating to 2.1.1.272
MetaCyc2.1.1.272
Rhea expert-curated reactions2.1.1.272
UniProtKB/Swiss-Prot
O87689, CBIH_PRIMG

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