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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.1.132

Accepted Name
Precorrin-6B C(5,15)-methyltransferase (decarboxylating).
Alternative Name(s)
Precorrin-6 methyltransferase.
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating).
Precorrin-6Y methylase.
Reaction catalysed
2 S-adenosyl-L-methionine + precorrin-6B <=> 2 S-adenosyl-L-homocysteine + precorrin-8X + CO(2)
Comment(s)
  • The enzyme, which participates in the aerobic adenosylcobalamin biosynthesis pathway, has S-adenosyl-L-methionine-dependent methyltransferase and decarboxylase activities.
  • The enzyme is a fusion protein with two active sites; one catalyzes the methylation at C(15) and the decarboxylation, while the other catalyzes the methylation at C(5).
Cross-references
BRENDA2.1.1.132
EC2PDB2.1.1.132
ExplorEnz2.1.1.132
PRIAM enzyme-specific profiles2.1.1.132
KEGG Ligand Database for Enzyme Nomenclature2.1.1.132
IUBMB Enzyme Nomenclature2.1.1.132
IntEnz2.1.1.132
MEDLINEFind literature relating to 2.1.1.132
MetaCyc2.1.1.132
UniProtKB/Swiss-Prot
P9WGA8, COBL_MYCTO;  P9WGA9, COBL_MYCTU;  Q9HZU0, COBL_PSEAE;  
P21921, COBL_SINSX;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-