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ENZYME entry: EC 2.1.1.132

Accepted Name
precorrin-6B C(5,15)-methyltransferase (decarboxylating).
Alternative Name(s)
precorrin-6 methyltransferase.
precorrin-6Y C(5,15)-methyltransferase (decarboxylating).
precorrin-6Y methylase.
Reaction catalysed
precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway.
  • The enzyme from the bacterium Pseudomonas denitrificans is a fusion protein with two active sites; one catalyzes the methylation at C-15 followed by decarboxylation of the C-12 acetate side chain, while the other catalyzes the methylation at C-5.
  • The corresponding activities in the anaerobic adenosylcobalamin biosynthesis pathway are catalyzed by EC 2.1.1.196 and EC 2.1.1.289.
Cross-references
BRENDA2.1.1.132
EC2PDB2.1.1.132
ExplorEnz2.1.1.132
PRIAM enzyme-specific profiles2.1.1.132
KEGG Ligand Database for Enzyme Nomenclature2.1.1.132
IUBMB Enzyme Nomenclature2.1.1.132
IntEnz2.1.1.132
MEDLINEFind literature relating to 2.1.1.132
MetaCyc2.1.1.132
Rhea expert-curated reactions2.1.1.132
UniProtKB/Swiss-Prot
P9WGA8, COBL_MYCTO;  P9WGA9, COBL_MYCTU;  Q9HZU0, COBL_PSEAE;  
P21921, COBL_SINSX;  

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