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ENZYME entry: EC 2.1.1.132
Accepted Name |
precorrin-6B C(5,15)-methyltransferase (decarboxylating).
|
Alternative Name(s) |
precorrin-6 methyltransferase. |
precorrin-6Y C(5,15)-methyltransferase (decarboxylating). |
precorrin-6Y methylase. |
Reaction catalysed |
precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine |
Comment(s) |
- The enzyme participates in the aerobic (late cobalt insertion)
adenosylcobalamin biosynthesis pathway.
- The enzyme from the bacterium Pseudomonas denitrificans is a fusion
protein with two active sites; one catalyzes the methylation at C-15
followed by decarboxylation of the C-12 acetate side chain, while the
other catalyzes the methylation at C-5.
- The corresponding activities in the anaerobic adenosylcobalamin
biosynthesis pathway are catalyzed by EC 2.1.1.196 and EC 2.1.1.289.
|
Cross-references |
BRENDA | 2.1.1.132 |
EC2PDB | 2.1.1.132 |
ExplorEnz | 2.1.1.132 |
PRIAM enzyme-specific profiles | 2.1.1.132 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.132 |
IUBMB Enzyme Nomenclature | 2.1.1.132 |
IntEnz | 2.1.1.132 |
MEDLINE | Find literature relating to 2.1.1.132 |
MetaCyc | 2.1.1.132 |
Rhea expert-curated reactions | 2.1.1.132 |
UniProtKB/Swiss-Prot |
|
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