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ENZYME

ENZYME entry: EC 2.1.1.196

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.196
Accepted Name
cobalt-precorrin-6B (C(15))-methyltransferase [decarboxylating]
Alternative Name(s)
cobalt-precorrin-6Y (C(15))-methyltransferase [decarboxylating]
Reaction catalysed
Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + S-adenosyl-L-homocysteine + CO2
Comment(s)
  • This enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyzes both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B.
  • The equivalent activity in the aerobic adenosylcobalamin biosynthesis pathway is catalyzed by the bifunctional enzyme EC 2.1.1.132.
Cross-references
BRENDA2.1.1.196
EC2PDB2.1.1.196
ExplorEnz2.1.1.196
KEGG Ligand Database for Enzyme Nomenclature2.1.1.196
IUBMB Enzyme Nomenclature2.1.1.196
MEDLINEFind literature relating to 2.1.1.196
MetaCyc2.1.1.196
Rhea expert-curated reactions2.1.1.196
UniProtKB/Swiss-Prot
O87694, CBIET_PRIMGO29526, CBIT_ARCFUQ9HPN4, CBIT_HALSA
Q8TI93, CBIT_METACQ57836, CBIT_METJAA4FWV6, CBIT_METM5
A9AA91, CBIT_METM6A6VGG1, CBIT_METM7Q8PY64, CBIT_METMA
P61820, CBIT_METMPA5UJR5, CBIT_METS3O26249, CBIT_METTH
A6UPM1, CBIT_METVSQ8ZZA9, CBIT_PYRAEA3MWC5, CBIT_PYRCJ
C3NJQ5, CBIT_SACI1C3MJI5, CBIT_SACI2C3N0H8, CBIT_SACI3
C3MTW8, CBIT_SACI4C4KJM8, CBIT_SACI6C3N8G6, CBIT_SACI7
Q97WC7, CBIT_SACS2Q8Z5M9, CBIT_SALTIQ05632, CBIT_SALTY
Q4JBL7, CBIT_SULACQ96ZL5, CBIT_SULTOQ9HKE4, CBIT_THEAC
Q97A64, CBIT_THEVO

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