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ENZYME entry: EC 2.1.1.196

Accepted Name
Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating).
Alternative Name(s)
Cobalt-precorrin-6Y (C(15))-methyltransferase (decarboxylating).
Reaction catalysed
S-adenosyl-L-methionine + cobalt-precorrin-6B <=> S-adenosyl-L-homocysteine + cobalt-precorrin-7 + CO(2)
Comment(s)
  • This enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyzes both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B.
  • The equivalent activity in the aerobic adenosylcobalamin biosynthesis pathway is catalyzed by the bifunctional enzyme EC 2.1.1.132.
Cross-references
BRENDA2.1.1.196
EC2PDB2.1.1.196
ExplorEnz2.1.1.196
PRIAM enzyme-specific profiles2.1.1.196
KEGG Ligand Database for Enzyme Nomenclature2.1.1.196
IUBMB Enzyme Nomenclature2.1.1.196
IntEnz2.1.1.196
MEDLINEFind literature relating to 2.1.1.196
MetaCyc2.1.1.196
Rhea expert-curated reactions2.1.1.196
UniProtKB/Swiss-Prot
O87694, CBIET_BACME;  O29526, CBIT_ARCFU;  Q9HPN4, CBIT_HALSA;  
Q8TI93, CBIT_METAC;  Q57836, CBIT_METJA;  A4FWV6, CBIT_METM5;  
A9AA91, CBIT_METM6;  A6VGG1, CBIT_METM7;  Q8PY64, CBIT_METMA;  
P61820, CBIT_METMP;  A5UJR5, CBIT_METS3;  O26249, CBIT_METTH;  
A6UPM1, CBIT_METVS;  Q8ZZA9, CBIT_PYRAE;  A3MWC5, CBIT_PYRCJ;  
Q97WC7, CBIT_SACS2;  Q8Z5M9, CBIT_SALTI;  Q05632, CBIT_SALTY;  
Q4JBL7, CBIT_SULAC;  C3N0H8, CBIT_SULIA;  C4KJM8, CBIT_SULIK;  
C3MJI5, CBIT_SULIL;  C3MTW8, CBIT_SULIM;  C3NJQ5, CBIT_SULIN;  
C3N8G6, CBIT_SULIY;  Q96ZL5, CBIT_SULTO;  Q9HKE4, CBIT_THEAC;  
Q97A64, CBIT_THEVO;  

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