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ENZYME entry: EC 2.1.1.157

Accepted Name
Sarcosine/dimethylglycine N-methyltransferase.
Alternative Name(s)
ApDMT.
Sarcosine dimethylglycine N-methyltransferase.
Sarcosine-dimethylglycine methyltransferase.
SDMT.
Reaction catalysed
2 S-adenosyl-L-methionine + sarcosine <=> 2 S-adenosyl-L-homocysteine + betaine
Comment(s)
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • The first enzyme, EC 2.1.1.156, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
  • Both of these enzymes can catalyze the formation of N,N-dimethylglycine from sarcosine.
  • The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
Cross-references
BRENDA2.1.1.157
EC2PDB2.1.1.157
ExplorEnz2.1.1.157
PRIAM enzyme-specific profiles2.1.1.157
KEGG Ligand Database for Enzyme Nomenclature2.1.1.157
IUBMB Enzyme Nomenclature2.1.1.157
IntEnz2.1.1.157
MEDLINEFind literature relating to 2.1.1.157
MetaCyc2.1.1.157
Rhea expert-curated reactions2.1.1.157
UniProtKB/Swiss-Prot
Q9KJ20, GSDMT_ACTHA;  Q83WC3, SDMT_APHHA;  Q9KJ21, SDMT_HALHR;  

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