Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.157

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.157
Accepted Name
sarcosine/dimethylglycine N-methyltransferase
Alternative Name(s)
ApDMT
sarcosine-dimethylglycine methyltransferase
sarcosine dimethylglycine N-methyltransferase
SDMT
Reaction catalysed
sarcosine + 2 S-adenosyl-L-methionine = glycine betaine + 2 S-adenosyl-L-homocysteine + 2 H(+)
Comment(s)
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • The first enzyme, EC 2.1.1.156, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
  • Both of these enzymes can catalyze the formation of N,N-dimethylglycine from sarcosine.
  • The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
Cross-references
Rhea expert-curated reactions2.1.1.157
ExplorEnz2.1.1.157
IUBMB Enzyme Nomenclature2.1.1.157
UniProtKB/Swiss-Prot
Q9KJ20, GSDMT_ACTHAQ83WC3, SDMT_APHHAQ9KJ21, SDMT_HALHR
BRENDA2.1.1.157
MetaCyc2.1.1.157
KEGG Ligand Database for Enzyme Nomenclature2.1.1.157
EC2PDB2.1.1.157
MEDLINEFind literature relating to 2.1.1.157

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-