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ENZYME

ENZYME entry: EC 2.1.1.157

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.157
Accepted Name
sarcosine/dimethylglycine N-methyltransferase
Alternative Name(s)
ApDMT
sarcosine-dimethylglycine methyltransferase
sarcosine dimethylglycine N-methyltransferase
SDMT
Reaction catalysed
sarcosine + 2 S-adenosyl-L-methionine = glycine betaine + 2 S-adenosyl-L-homocysteine + 2 H(+)
Comment(s)
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • The first enzyme, EC 2.1.1.156, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
  • Both of these enzymes can catalyze the formation of N,N-dimethylglycine from sarcosine.
  • The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
Cross-references
BRENDA2.1.1.157
EC2PDB2.1.1.157
ExplorEnz2.1.1.157
KEGG Ligand Database for Enzyme Nomenclature2.1.1.157
IUBMB Enzyme Nomenclature2.1.1.157
MEDLINEFind literature relating to 2.1.1.157
MetaCyc2.1.1.157
Rhea expert-curated reactions2.1.1.157
UniProtKB/Swiss-Prot
Q9KJ20, GSDMT_ACTHAQ83WC3, SDMT_APHHAQ9KJ21, SDMT_HALHR

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