ENZYME entry: EC 2.1.1.157
Accepted Name |
Sarcosine/dimethylglycine N-methyltransferase.
|
Alternative Name(s) |
ApDMT. |
Sarcosine dimethylglycine N-methyltransferase. |
Sarcosine-dimethylglycine methyltransferase. |
SDMT. |
Reaction catalysed |
2 S-adenosyl-L-methionine + sarcosine <=> 2 S-adenosyl-L-homocysteine + betaine |
Comment(s) |
- Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece
halophytica synthesize betaine from glycine by a three-step
methylation process.
- The first enzyme, EC 2.1.1.156, leads to the formation of either
sarcosine or N,N-dimethylglycine, which is further methylated to
yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
- Both of these enzymes can catalyze the formation of
N,N-dimethylglycine from sarcosine.
- The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
|
Cross-references |
BRENDA | 2.1.1.157 |
EC2PDB | 2.1.1.157 |
ExplorEnz | 2.1.1.157 |
PRIAM enzyme-specific profiles | 2.1.1.157 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.157 |
IUBMB Enzyme Nomenclature | 2.1.1.157 |
IntEnz | 2.1.1.157 |
MEDLINE | Find literature relating to 2.1.1.157 |
MetaCyc | 2.1.1.157 |
Rhea expert-curated reactions | 2.1.1.157 |
UniProtKB/Swiss-Prot |
|
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