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ENZYME

ENZYME entry: EC 2.1.1.156

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.156
Accepted Name
glycine/sarcosine N-methyltransferase
Alternative Name(s)
glycine-sarcosine methyltransferase
glycine sarcosine N-methyltransferase
GMT
GSMT
Reaction catalysed
glycine + 2 S-adenosyl-L-methionine = N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine + 2 H(+)
Comment(s)
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
  • Differs from EC 2.1.1.20, as it can further methylate the product of the first reaction.
  • Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction.
Cross-references
BRENDA2.1.1.156
EC2PDB2.1.1.156
ExplorEnz2.1.1.156
KEGG Ligand Database for Enzyme Nomenclature2.1.1.156
IUBMB Enzyme Nomenclature2.1.1.156
MEDLINEFind literature relating to 2.1.1.156
MetaCyc2.1.1.156
Rhea expert-curated reactions2.1.1.156
UniProtKB/Swiss-Prot
Q9KJ20, GSDMT_ACTHAQ83WC4, GSMT_APHHAQ9KJ22, GSMT_HALHR
Q7U4Z8, GSMT_PARMW

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