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ENZYME entry: EC 2.1.1.167

Accepted Name
27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + guanosine(2922) in 27S pre-rRNA <=> S-adenosyl-L-homocysteine + 2'-O-methylguanosine(2922) in 27S pre-rRNA
Comment(s)
  • Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyzes the formation of 2'-O-methylguanosine(2922), a universally conserved position of the catalytic center of the ribosome that is essential for translation.
  • 2'-O-methylguanosine(2922) is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA.
  • In absence of snR52, Spb1p can also catalyze the formation of uridine(2921).
Cross-references
BRENDA2.1.1.167
EC2PDB2.1.1.167
ExplorEnz2.1.1.167
PRIAM enzyme-specific profiles2.1.1.167
KEGG Ligand Database for Enzyme Nomenclature2.1.1.167
IUBMB Enzyme Nomenclature2.1.1.167
IntEnz2.1.1.167
MEDLINEFind literature relating to 2.1.1.167
MetaCyc2.1.1.167
Rhea expert-curated reactions2.1.1.167
UniProtKB/Swiss-Prot
P25582, SPB1_YEAST

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