A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.1.1.167
Accepted Name |
27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase.
|
Reaction catalysed |
S-adenosyl-L-methionine + guanosine(2922) in 27S pre-rRNA <=> S-adenosyl-L-homocysteine + 2'-O-methylguanosine(2922) in 27S pre-rRNA |
Comment(s) |
- Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that
catalyzes the formation of 2'-O-methylguanosine(2922), a universally
conserved position of the catalytic center of the ribosome that is
essential for translation.
- 2'-O-methylguanosine(2922) is formed at a later stage of the
processing, during the maturation of of the 27S pre-rRNA.
- In absence of snR52, Spb1p can also catalyze the formation of
uridine(2921).
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Cross-references |
BRENDA | 2.1.1.167 |
EC2PDB | 2.1.1.167 |
ExplorEnz | 2.1.1.167 |
PRIAM enzyme-specific profiles | 2.1.1.167 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.167 |
IUBMB Enzyme Nomenclature | 2.1.1.167 |
IntEnz | 2.1.1.167 |
MEDLINE | Find literature relating to 2.1.1.167 |
MetaCyc | 2.1.1.167 |
UniProtKB/Swiss-Prot |
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