ENZYME

ENZYME entry: EC 2.1.1.167

Accepted Name

27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase.

Reaction catalysed

S-adenosyl-L-methionine + guanosine(2922) in 27S pre-rRNA <=> S-adenosyl-L-homocysteine + 2'-O-methylguanosine(2922) in 27S pre-rRNA

Comment(s)

Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyzes the formation of 2'-O-methylguanosine(2922), a universally conserved position of the catalytic center of the ribosome that is essential for translation.
2'-O-methylguanosine(2922) is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA.
In absence of snR52, Spb1p can also catalyze the formation of uridine(2921).

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature