Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.188

Accepted Name
23S rRNA (guanine(748)-N(1))-methyltransferase
Alternative Name(s)
23S rRNA m(1)G(748) methyltransferase
rRNA large subunit methyltransferase II
tylosin-resistance methyltransferase RlmA(II)
Reaction catalysed
guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme specifically methylates guanine(748) at N(1) in 23S rRNA.
  • The methyltransferase RlmA(II) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae.
  • Formerly EC 2.1.1.51.
Cross-references
BRENDA2.1.1.188
EC2PDB2.1.1.188
ExplorEnz2.1.1.188
PRIAM enzyme-specific profiles2.1.1.188
KEGG Ligand Database for Enzyme Nomenclature2.1.1.188
IUBMB Enzyme Nomenclature2.1.1.188
IntEnz2.1.1.188
MEDLINEFind literature relating to 2.1.1.188
MetaCyc2.1.1.188
Rhea expert-curated reactions2.1.1.188
UniProtKB/Swiss-Prot
Q9S1M6, RLMA2_STRFR

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-