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ENZYME entry: EC 2.1.1.20

Accepted Name
glycine N-methyltransferase.
Alternative Name(s)
glycine methyltransferase.
Reaction catalysed
glycine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sarcosine
Comment(s)
  • Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine.
  • Inhibited by 5-methyltetrahydrofolate pentaglutamate.
  • Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.
Cross-references
BRENDA2.1.1.20
EC2PDB2.1.1.20
ExplorEnz2.1.1.20
PRIAM enzyme-specific profiles2.1.1.20
KEGG Ligand Database for Enzyme Nomenclature2.1.1.20
IUBMB Enzyme Nomenclature2.1.1.20
IntEnz2.1.1.20
MEDLINEFind literature relating to 2.1.1.20
MetaCyc2.1.1.20
Rhea expert-curated reactions2.1.1.20
UniProtKB/Swiss-Prot
Q14749, GNMT_HUMAN;  Q9QXF8, GNMT_MOUSE;  Q29555, GNMT_PIG;  
Q29513, GNMT_RABIT;  P13255, GNMT_RAT;  

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