ENZYME entry: EC 2.1.1.215

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.215

Accepted Name

tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase

Reaction catalysed

guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)

Comment(s)

The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216).
However, it catalyzes the double methylation of guanines at both positions 26 and 27 of tRNA.
Formerly EC 2.1.1.32.

Cross-references

BRENDA

2.1.1.215

EC2PDB

2.1.1.215

ExplorEnz

2.1.1.215

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.215

IUBMB Enzyme Nomenclature

2.1.1.215

MEDLINE

Find literature relating to 2.1.1.215

MetaCyc

2.1.1.215

Rhea expert-curated reactions

2.1.1.215

UniProtKB/Swiss-Prot

O67010, TRM1_AQUAE

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-