ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.1.215

Accepted Name

tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase.

Reaction catalysed

4 S-adenosyl-L-methionine + guanine(26)/guanine(27) in tRNA <=> 4 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26)/N(2)-dimethylguanine(27) in tRNA

Comment(s)

The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216).
However, it catalyzes the double methylation of guanines at both positions 26 and 27 of tRNA.
Formerly EC 2.1.1.32.

Cross-references

BRENDA

2.1.1.215

EC2PDB

2.1.1.215

ExplorEnz

2.1.1.215

PRIAM enzyme-specific profiles

2.1.1.215

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.215

IUBMB Enzyme Nomenclature