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ENZYME entry: EC 2.1.1.215

Accepted Name
tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase.
Reaction catalysed
4 S-adenosyl-L-methionine + guanine(26)/guanine(27) in tRNA <=> 4 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26)/N(2)-dimethylguanine(27) in tRNA
Comment(s)
  • The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216).
  • However, it catalyzes the double methylation of guanines at both positions 26 and 27 of tRNA.
  • Formerly EC 2.1.1.32.
Cross-references
BRENDA2.1.1.215
EC2PDB2.1.1.215
ExplorEnz2.1.1.215
PRIAM enzyme-specific profiles2.1.1.215
KEGG Ligand Database for Enzyme Nomenclature2.1.1.215
IUBMB Enzyme Nomenclature2.1.1.215
IntEnz2.1.1.215
MEDLINEFind literature relating to 2.1.1.215
MetaCyc2.1.1.215
Rhea expert-curated reactions2.1.1.215
UniProtKB/Swiss-Prot
O67010, TRM1_AQUAE

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