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ENZYME entry: EC 2.1.1.218

Accepted Name
tRNA (adenine(9)-N(1))-methyltransferase.
Alternative Name(s)
tRNA m(1)A(9)-methyltransferase.
tRNA(m(1)G(9)/m(1)A(9))-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + adenine(9) in tRNA <=> S-adenosyl-L-homocysteine + N(1)-methyladenine(9) in tRNA
Comment(s)
  • The enzyme from Sulfolobus acidocaldarius specifically methylates adenine(9) in tRNA.
  • The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of guanine(9) in tRNA (cf. EC 2.1.1.221).
  • Formerly EC 2.1.1.36.
Cross-references
BRENDA2.1.1.218
EC2PDB2.1.1.218
ExplorEnz2.1.1.218
PRIAM enzyme-specific profiles2.1.1.218
KEGG Ligand Database for Enzyme Nomenclature2.1.1.218
IUBMB Enzyme Nomenclature2.1.1.218
IntEnz2.1.1.218
MEDLINEFind literature relating to 2.1.1.218
MetaCyc2.1.1.218
Rhea expert-curated reactions2.1.1.218
UniProtKB/Swiss-Prot
Q2KI45, TM10C_BOVIN;  Q7L0Y3, TM10C_HUMAN;  Q3UFY8, TM10C_MOUSE;  
Q5U2R4, TM10C_RAT;  A4IHS0, TM10C_XENTR;  Q4J894, TRM10_SULAC;  
Q5JD38, TRM10_THEKO;  

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