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ENZYME

ENZYME entry: EC 2.1.1.221

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.221
Accepted Name
tRNA (guanine(9)-N(1))-methyltransferase
Alternative Name(s)
tRNA m(1)G(9)-methyltransferase
tRNA m(1)G(9) MTase
Reaction catalysed
guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzyme from Saccharomyces cerevisiae specifically methylates guanine(9).
  • The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of adenine(9) in tRNA (cf. EC 2.1.1.218).
  • Formerly EC 2.1.1.31.
Cross-references
BRENDA2.1.1.221
EC2PDB2.1.1.221
ExplorEnz2.1.1.221
KEGG Ligand Database for Enzyme Nomenclature2.1.1.221
IUBMB Enzyme Nomenclature2.1.1.221
MEDLINEFind literature relating to 2.1.1.221
MetaCyc2.1.1.221
Rhea expert-curated reactions2.1.1.221
UniProtKB/Swiss-Prot
Q3MHI8, TM10A_BOVINQ9VR56, TM10A_DROMEQ8TBZ6, TM10A_HUMAN
Q8C1Z8, TM10A_MOUSEQ4KLI2, TM10A_RATQ66JJ4, TM10A_XENTR
Q08DP1, TM10B_BOVINQ08BM0, TM10B_DANREQ6PF06, TM10B_HUMAN
Q9D075, TM10B_MOUSEQ5RJK3, TM10B_RATQ2KI45, TM10C_BOVIN
Q7L0Y3, TM10C_HUMANQ3UFY8, TM10C_MOUSEQ5U2R4, TM10C_RAT
A4IHS0, TM10C_XENTRQ4WXA1, TRM10_ASPFUQ59Q39, TRM10_CANAL
Q6FQB2, TRM10_CANGAP0CS10, TRM10_CRYD1P0CS11, TRM10_CRYD3
Q6BWG3, TRM10_DEBHAQ5B8X0, TRM10_EMENIQ75A17, TRM10_EREGS
Q4I8X0, TRM10_GIBZEQ6CUM6, TRM10_KLULAO14214, TRM10_SCHPO
Q5JD38, TRM10_THEKOQ6C1W9, TRM10_YARLIQ12400, TRM10_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-