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ENZYME

ENZYME entry: EC 2.1.1.233

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.233
Accepted Name
[phosphatase 2A protein]-leucine-carboxy methyltransferase
Alternative Name(s)
leucine carboxy methyltransferase-1
Reaction catalysed
[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine
Comment(s)
  • Methylates the C-terminal leucine of phosphatase 2A.
  • A key regulator of protein phosphatase 2A.
  • The methyl ester is hydrolyzed by EC 3.1.1.89.
  • Occurs mainly in the cytoplasm, Golgi region and late endosomes.
Cross-references
BRENDA2.1.1.233
EC2PDB2.1.1.233
ExplorEnz2.1.1.233
KEGG Ligand Database for Enzyme Nomenclature2.1.1.233
IUBMB Enzyme Nomenclature2.1.1.233
MEDLINEFind literature relating to 2.1.1.233
MetaCyc2.1.1.233
Rhea expert-curated reactions2.1.1.233
UniProtKB/Swiss-Prot
Q8VY08, LCMT1_ARATHQ4WS57, LCMT1_ASPFUQ3T0H0, LCMT1_BOVIN
Q60YU0, LCMT1_CAEBRP46554, LCMT1_CAEELQ5A387, LCMT1_CANAL
Q6FUI5, LCMT1_CANGAP0CO56, LCMT1_CRYD1P0CO57, LCMT1_CRYD3
Q6BQD2, LCMT1_DEBHAQ5AQJ2, LCMT1_EMENIQ759U5, LCMT1_EREGS
Q4ICG8, LCMT1_GIBZEQ9UIC8, LCMT1_HUMANQ6CWW0, LCMT1_KLULA
Q4P4G2, LCMT1_MYCMDQ7SAP7, LCMT1_NEUCRQ6P4Z6, LCMT1_RAT
O94257, LCMT1_SCHPOQ6C997, LCMT1_YARLIQ04081, LCMT1_YEAST

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