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ENZYME entry: EC 3.1.1.89

Accepted Name
Protein phosphatase methylesterase-1.
Reaction catalysed
[Phosphatase 2A protein]-leucine methyl ester + H(2)O <=> [phosphatase 2A protein]-leucine + methanol
Comment(s)
  • A key regulator of protein phosphatase 2A.
  • The methyl ester is formed by EC 2.1.1.233.
  • Occurs mainly in the nucleus.
Cross-references
BRENDA3.1.1.89
EC2PDB3.1.1.89
ExplorEnz3.1.1.89
PRIAM enzyme-specific profiles3.1.1.89
KEGG Ligand Database for Enzyme Nomenclature3.1.1.89
IUBMB Enzyme Nomenclature3.1.1.89
IntEnz3.1.1.89
MEDLINEFind literature relating to 3.1.1.89
MetaCyc3.1.1.89
Rhea expert-curated reactions3.1.1.89
UniProtKB/Swiss-Prot
Q74Z47, PPME1_ASHGO;  Q4WKB2, PPME1_ASPFU;  Q2URJ0, PPME1_ASPOR;  
Q58DN4, PPME1_BOVIN;  Q9BIB3, PPME1_CAEEL;  Q5ALW7, PPME1_CANAL;  
Q6FNL6, PPME1_CANGA;  P0CO63, PPME1_CRYNB;  P0CO62, PPME1_CRYNJ;  
Q6BZG3, PPME1_DEBHA;  Q54TN3, PPME1_DICDI;  Q5BGN7, PPME1_EMENI;  
Q4IQC1, PPME1_GIBZE;  Q9Y570, PPME1_HUMAN;  Q6CQZ5, PPME1_KLULA;  
Q8BVQ5, PPME1_MOUSE;  Q7SGG8, PPME1_NEUCR;  Q5R4F9, PPME1_PONAB;  
Q4FZT2, PPME1_RAT;  Q9P7D2, PPME1_SCHPO;  Q6CGE1, PPME1_YARLI;  
P38796, PPME1_YEAST;  

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