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ENZYME

ENZYME entry: EC 2.1.1.248

Accepted Name
[methylamine--corrinoid protein] Co-methyltransferase
Alternative Name(s)
monomethylamine methyltransferase
Reaction catalysed
Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)
Comment(s)
  • The enzyme, which catalyzes the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine.
  • The enzyme contains the unusual amino acid pyrrolysine.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
  • During methylation the cobalt is oxidized to the Co(III) state.
  • The methylated corrinoid protein is substrate for EC 2.1.1.247.
Cross-references
BRENDA2.1.1.248
EC2PDB2.1.1.248
ExplorEnz2.1.1.248
PRIAM enzyme-specific profiles2.1.1.248
KEGG Ligand Database for Enzyme Nomenclature2.1.1.248
IUBMB Enzyme Nomenclature2.1.1.248
IntEnz2.1.1.248
MEDLINEFind literature relating to 2.1.1.248
MetaCyc2.1.1.248
Rhea expert-curated reactions2.1.1.248
UniProtKB/Swiss-Prot
P58865, MTMB1_METACO30642, MTMB1_METBAQ46E72, MTMB1_METBF
P58866, MTMB2_METACQ9P9L4, MTMB2_METBAP0C0W3, MTMB2_METBF
P0C0W4, MTMB3_METBFP58969, MTMB_METMA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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