ENZYME entry: EC 2.1.1.247

Accepted Name

[Methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase.

Alternative Name(s)

MT2-A.

Reaction catalysed

A [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M <=> methyl-CoM + a [Co(I) methylamine-specific corrinoid protein]

Cofactor(s)

Zn(2+).

Comment(s)

The enzyme, which is involved in methanogenesis from mono-, di-, and trimethylamine, catalyzes the transfer of a methyl group bound to the cobalt cofactor of several corrinoid proteins (mono-, di-, and trimethylamine-specific corrinoid proteins, cf. EC 2.1.1.248, EC 2.1.1.249 and EC 2.1.1.250) to coenzyme M, forming the substrate for EC 2.8.4.1, the enzyme that catalyzes the final step in methanogenesis.

Cross-references

BRENDA

2.1.1.247

EC2PDB

2.1.1.247

ExplorEnz

2.1.1.247

PRIAM enzyme-specific profiles

2.1.1.247

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.247

IUBMB Enzyme Nomenclature

2.1.1.247

IntEnz

2.1.1.247

MEDLINE

Find literature relating to 2.1.1.247

MetaCyc

2.1.1.247

UniProtKB/Swiss-Prot

P58869, MTBA_METAC;

O30640, MTBA_METBA;

P58984, MTBA_METMA;

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