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ENZYME entry: EC 2.1.1.249

Accepted Name
[dimethylamine--corrinoid protein] Co-methyltransferase.
Alternative Name(s)
dimethylamine methyltransferase.
Reaction catalysed
Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine
Comment(s)
  • The enzyme, which catalyzes the transfer of a methyl group from dimethylamine to a dimethylamine-specific corrinoid protein (MtbC), is involved in methanogenesis from dimethylamine.
  • The enzyme contains the unusual amino acid pyrrolysine.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
  • During methylation the cobalt is oxidized to the Co(III) state.
  • The methylated corrinoid protein is substrate for EC 2.1.1.247.
Cross-references
BRENDA2.1.1.249
EC2PDB2.1.1.249
ExplorEnz2.1.1.249
PRIAM enzyme-specific profiles2.1.1.249
KEGG Ligand Database for Enzyme Nomenclature2.1.1.249
IUBMB Enzyme Nomenclature2.1.1.249
IntEnz2.1.1.249
MEDLINEFind literature relating to 2.1.1.249
MetaCyc2.1.1.249
Rhea expert-curated reactions2.1.1.249
UniProtKB/Swiss-Prot
Q8TTA5, MTBB1_METAC;  O93661, MTBB1_METBA;  P0C0W5, MTBB1_METBF;  
P58970, MTBB1_METMA;  Q8TS72, MTBB2_METAC;  Q9P9N0, MTBB2_METBA;  
P0C0W6, MTBB2_METBF;  P58971, MTBB2_METMA;  Q8TN68, MTBB3_METAC;  
Q9P9M9, MTBB3_METBA;  P58972, MTBB3_METMA;  

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