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ENZYME entry: EC 2.1.1.249
Accepted Name |
[dimethylamine--corrinoid protein] Co-methyltransferase.
|
Alternative Name(s) |
dimethylamine methyltransferase. |
Reaction catalysed |
Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine |
Comment(s) |
- The enzyme, which catalyzes the transfer of a methyl group from
dimethylamine to a dimethylamine-specific corrinoid protein (MtbC),
is involved in methanogenesis from dimethylamine.
- The enzyme contains the unusual amino acid pyrrolysine.
- Methylation of the corrinoid protein requires the central cobalt to
be in the Co(I) state.
- During methylation the cobalt is oxidized to the Co(III) state.
- The methylated corrinoid protein is substrate for EC 2.1.1.247.
|
Cross-references |
BRENDA | 2.1.1.249 |
EC2PDB | 2.1.1.249 |
ExplorEnz | 2.1.1.249 |
PRIAM enzyme-specific profiles | 2.1.1.249 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.249 |
IUBMB Enzyme Nomenclature | 2.1.1.249 |
IntEnz | 2.1.1.249 |
MEDLINE | Find literature relating to 2.1.1.249 |
MetaCyc | 2.1.1.249 |
Rhea expert-curated reactions | 2.1.1.249 |
UniProtKB/Swiss-Prot |
Q8TTA5, MTBB1_METAC; | O93661, MTBB1_METBA; | P0C0W5, MTBB1_METBF; |
P58970, MTBB1_METMA; | Q8TS72, MTBB2_METAC; | Q9P9N0, MTBB2_METBA; |
P0C0W6, MTBB2_METBF; | P58971, MTBB2_METMA; | Q8TN68, MTBB3_METAC; |
Q9P9M9, MTBB3_METBA; | P58972, MTBB3_METMA; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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