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ENZYME

ENZYME entry: EC 2.1.1.250

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.250
Accepted Name
[trimethylamine--corrinoid protein] Co-methyltransferase
Alternative Name(s)
trimethylamine methyltransferase
Reaction catalysed
Co(I)-[trimethylamine-specific corrinoid protein] + trimethylamine + H(+) = methyl-Co(III)-[trimethylamine-specific corrinoid protein] + dimethylamine
Comment(s)
  • The enzyme, which catalyzes the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine.
  • The enzyme contains the unusual amino acid pyrrolysine.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
  • During methylation the cobalt is oxidized to the Co(III) state.
  • The methylated corrinoid protein is substrate for EC 2.1.1.247.
Cross-references
BRENDA2.1.1.250
EC2PDB2.1.1.250
ExplorEnz2.1.1.250
KEGG Ligand Database for Enzyme Nomenclature2.1.1.250
IUBMB Enzyme Nomenclature2.1.1.250
MEDLINEFind literature relating to 2.1.1.250
MetaCyc2.1.1.250
Rhea expert-curated reactions2.1.1.250
UniProtKB/Swiss-Prot
Q8TTA9, MTTB1_METACP58973, MTTB1_METMAQ8TS73, MTTB2_METAC
P58974, MTTB2_METMAQ18TV3, MTTB_DESHDQ24MI3, MTTB_DESHY
O93658, MTTB_METBAP0C0W7, MTTB_METBFQ12TR2, MTTB_METBU
Q9P995, MTTB_METTE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-