ENZYME entry: EC 2.1.1.258

Accepted Name

5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase

Reaction catalysed

(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)

Comment(s)

Catalyzes the transfer of a methyl group from the N(5) group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein.
Involved, together with EC 1.2.7.4 and EC 2.3.1.169, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.

Cross-references

BRENDA

2.1.1.258

EC2PDB

2.1.1.258

ExplorEnz

2.1.1.258

PRIAM enzyme-specific profiles

2.1.1.258

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.258

IUBMB Enzyme Nomenclature

2.1.1.258

IntEnz

2.1.1.258

MEDLINE

Find literature relating to 2.1.1.258

MetaCyc

2.1.1.258

Rhea expert-curated reactions

2.1.1.258

UniProtKB/Swiss-Prot

Q46389, ACSE_MOOTH

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