ENZYME entry: EC 2.1.1.282

Accepted Name

tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]- methyltransferase

Alternative Name(s)

tRNA-yW synthesizing enzyme-3

Reaction catalysed

4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine

Comment(s)

The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs.
These modifications are important for translational reading-frame maintenance.
The enzyme is found in all eukaryotes and in some archaea, but not in bacteria.
The eukaryotic enzyme is involved in the biosynthesis of wybutosine.

Cross-references

BRENDA

2.1.1.282

EC2PDB

2.1.1.282

ExplorEnz

2.1.1.282

PRIAM enzyme-specific profiles

2.1.1.282

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.282

IUBMB Enzyme Nomenclature

2.1.1.282

IntEnz

2.1.1.282

MEDLINE

Find literature relating to 2.1.1.282

MetaCyc

2.1.1.282

Rhea expert-curated reactions

2.1.1.282

UniProtKB/Swiss-Prot

Q8W4K1, TYW23_ARATH	Q8H4D4, TYW23_ORYSJ	Q9V074, TYW31_PYRAB
Q8U1V7, TYW31_PYRFU	O58796, TYW31_PYRHO	Q5JFK6, TYW31_THEKO
Q9V1Y5, TYW32_PYRAB	Q8TZG0, TYW32_PYRFU	O59533, TYW32_PYRHO
Q5JES6, TYW32_THEKO	Q9YDV3, TYW3_AERPE	O28220, TYW3_ARCFU
Q5E9U4, TYW3_BOVIN	Q6DHJ1, TYW3_DANRE	Q6IPR3, TYW3_HUMAN
Q58905, TYW3_METJA	Q8BSA9, TYW3_MOUSE	Q19QT9, TYW3_PIG
Q5R5S9, TYW3_PONAB	Q9UX16, TYW3_SACS2	Q9UTA5, TYW3_SCHPO
C6A5A3, TYW3_THESM	Q641F8, TYW3_XENLA	P53177, TYW3_YEAST

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