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ENZYME

ENZYME entry: EC 2.1.1.299

Accepted Name
protein N-terminal monomethyltransferase
Alternative Name(s)
N-terminal monomethylase
Reaction catalysed
  • N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
  • N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
  • N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine
Comment(s)
  • This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved.
  • In contrast to EC 2.1.1.244, the protein only adds one methyl group to the N-terminal.
Cross-references
BRENDA2.1.1.299
EC2PDB2.1.1.299
ExplorEnz2.1.1.299
PRIAM enzyme-specific profiles2.1.1.299
KEGG Ligand Database for Enzyme Nomenclature2.1.1.299
IUBMB Enzyme Nomenclature2.1.1.299
IntEnz2.1.1.299
MEDLINEFind literature relating to 2.1.1.299
MetaCyc2.1.1.299
Rhea expert-curated reactions2.1.1.299
UniProtKB/Swiss-Prot
B8JM82, NTM1B_DANREQ5VVY1, NTM1B_HUMANB2RXM4, NTM1B_MOUSE
D3ZVR1, NTM1B_RAT

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