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ENZYME

ENZYME entry: EC 2.1.1.342

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.342
Accepted Name
anaerobilin synthase
Reaction catalysed
2 reduced [flavodoxin] + heme b + 2 S-adenosyl-L-methionine = anaerobilin + 2 oxidized [flavodoxin] + Fe(2+) + 5'-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme, studied from the bacterium Escherichia coli O157:H7, is a radical SAM (AdoMet) enzyme that is involved in heme degradation and iron utilization under anaerobic conditions.
  • The enzyme uses two SAM molecules for the reaction.
  • The first molecule is used to generate a 5'-deoxyadenosyl radical, which abstracts a hydrogen atom from the methyl group of the second SAM molecule.
  • The newly formed methylene radical attacks the substrate, causing a rearrangement of the porphyrin ring that results in the liberation of iron.
Cross-references
BRENDA2.1.1.342
EC2PDB2.1.1.342
ExplorEnz2.1.1.342
KEGG Ligand Database for Enzyme Nomenclature2.1.1.342
IUBMB Enzyme Nomenclature2.1.1.342
MEDLINEFind literature relating to 2.1.1.342
MetaCyc2.1.1.342
Rhea expert-curated reactions2.1.1.342
UniProtKB/Swiss-Prot
A0A384LP51, CHUW_ECO57

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