A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 22.214.171.1242
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|2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe(2+) + 2 oxidized flavodoxin|
- The enzyme, studied from the bacterium Escherichia coli O157:H7, is a
radical SAM (AdoMet) enzyme that is involved in heme degradation and
iron utilization under anaerobic conditions.
- The enzyme uses two SAM molecules for the reaction.
- The first molecule is used to generate a 5'-deoxyadenosyl radical,
which abstracts a hydrogen atom from the methyl group of the second
- The newly formed methylene radical attacks the substrate, causing a
rearrangement of the porphyrin ring that results in the liberation of
|PRIAM enzyme-specific profiles||126.96.36.1992|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.522|
|IUBMB Enzyme Nomenclature||184.108.40.2062|
|MEDLINE||Find literature relating to 220.127.116.112|
entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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