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ENZYME entry: EC

Accepted Name
anaerobilin synthase
Reaction catalysed
heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine
  • The enzyme, studied from the bacterium Escherichia coli O157:H7, is a radical SAM (AdoMet) enzyme that is involved in heme degradation and iron utilization under anaerobic conditions.
  • The enzyme uses two SAM molecules for the reaction.
  • The first molecule is used to generate a 5'-deoxyadenosyl radical, which abstracts a hydrogen atom from the methyl group of the second SAM molecule.
  • The newly formed methylene radical attacks the substrate, causing a rearrangement of the porphyrin ring that results in the liberation of iron.
PRIAM enzyme-specific profiles2.1.1.342
KEGG Ligand Database for Enzyme Nomenclature2.1.1.342
IUBMB Enzyme Nomenclature2.1.1.342
MEDLINEFind literature relating to
Rhea expert-curated reactions2.1.1.342
A0A384LP51, CHUW_ECO57

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