ENZYME entry: EC 2.1.1.346
Accepted Name |
U6 snRNA m(6)A methyltransferase.
|
Reaction catalysed |
S-adenosyl-L-methionine + adenine in U6 snRNA <=> S-adenosyl-L-homocysteine + N(6)-methyladenine in U6 snRNA |
Comment(s) |
- This enzyme, found in vertebrates, methylates a specific adenine in a
hairpin structure of snRNA.
- The effects of the binding of the methyltransferase to its substrate
is important for the regulation of the activity of an isoform of
EC 2.5.1.6, that produces S-adenosyl-L-methionine.
- The enzyme also binds (and maybe methylates) the lncRNAs XIST and
MALAT1 as well as a number of pre-mRNAs at specific positions often
found in the intronic regions.
|
Cross-references |
BRENDA | 2.1.1.346 |
EC2PDB | 2.1.1.346 |
ExplorEnz | 2.1.1.346 |
PRIAM enzyme-specific profiles | 2.1.1.346 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.346 |
IUBMB Enzyme Nomenclature | 2.1.1.346 |
IntEnz | 2.1.1.346 |
MEDLINE | Find literature relating to 2.1.1.346 |
MetaCyc | 2.1.1.346 |
Rhea expert-curated reactions | 2.1.1.346 |
UniProtKB/Swiss-Prot |
Q61J97, MET16_CAEBR; | Q09357, MET16_CAEEL; | Q5ZIA0, MET16_CHICK; |
Q6DC64, MET16_DANRE; | Q554C9, MET16_DICDI; | Q7K3B9, MET16_DROME; |
Q290Z2, MET16_DROPS; | Q86W50, MET16_HUMAN; | Q9CQG2, MET16_MOUSE; |
Q6GR37, MET16_XENLA; | O42662, MTL16_SCHPO; |
|
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