Home  |  Contact

ENZYME entry: EC

Accepted Name
U6 snRNA m(6)A methyltransferase.
Reaction catalysed
adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine
  • This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA.
  • The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC, that produces S-adenosyl-L-methionine.
  • The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions.
PRIAM enzyme-specific profiles2.1.1.346
KEGG Ligand Database for Enzyme Nomenclature2.1.1.346
IUBMB Enzyme Nomenclature2.1.1.346
MEDLINEFind literature relating to
Rhea expert-curated reactions2.1.1.346
Q61J97, MET16_CAEBR;  Q09357, MET16_CAEEL;  Q5ZIA0, MET16_CHICK;  
Q6DC64, MET16_DANRE;  Q554C9, MET16_DICDI;  Q7K3B9, MET16_DROME;  
Q290Z2, MET16_DROPS;  Q86W50, MET16_HUMAN;  Q9CQG2, MET16_MOUSE;  
Q6GR37, MET16_XENLA;  O42662, MTL16_SCHPO;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-