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ENZYME

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ENZYME entry: EC 2.1.1.346

Accepted Name
U6 snRNA m(6)A methyltransferase
Reaction catalysed
adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine
Comment(s)
  • This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA.
  • The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, that produces S-adenosyl-L-methionine.
  • The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions.
Cross-references
BRENDA2.1.1.346
EC2PDB2.1.1.346
ExplorEnz2.1.1.346
PRIAM enzyme-specific profiles2.1.1.346
KEGG Ligand Database for Enzyme Nomenclature2.1.1.346
IUBMB Enzyme Nomenclature2.1.1.346
IntEnz2.1.1.346
MEDLINEFind literature relating to 2.1.1.346
MetaCyc2.1.1.346
Rhea expert-curated reactions2.1.1.346
UniProtKB/Swiss-Prot
Q61J97, MET16_CAEBRQ09357, MET16_CAEELQ5ZIA0, MET16_CHICK
Q6DC64, MET16_DANREQ554C9, MET16_DICDIQ7K3B9, MET16_DROME
Q290Z2, MET16_DROPSQ86W50, MET16_HUMANQ9CQG2, MET16_MOUSE
Q6GR37, MET16_XENLAO42662, MTL16_SCHPO

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