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ENZYME entry: EC 2.1.1.35

Accepted Name
tRNA (uracil(54)-C(5))-methyltransferase.
Alternative Name(s)
5-methyluridine(54) tRNA methyltransferase.
m(5)U(54)-methyltransferase.
m5U-methyltransferase.
ribothymidyl synthase.
RUMT.
transfer RNA uracil(54) 5-methyltransferase.
transfer RNA uracil(54) methylase.
transfer RNA uracil 5-methyltransferase.
transfer RNA uracil methylase.
tRNA:m(5)U(54)-methyltransferase.
tRNA(m(5)U(54))methyltransferase.
tRNA(uracil-54,C(5))-methyltransferase.
tRNA uracil(54) 5-methyltransferase.
tRNA uracil 5-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine
Comment(s)
Unlike this enzyme, EC 2.1.1.74 uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54.
Cross-references
BRENDA2.1.1.35
EC2PDB2.1.1.35
ExplorEnz2.1.1.35
PRIAM enzyme-specific profiles2.1.1.35
KEGG Ligand Database for Enzyme Nomenclature2.1.1.35
IUBMB Enzyme Nomenclature2.1.1.35
IntEnz2.1.1.35
MEDLINEFind literature relating to 2.1.1.35
MetaCyc2.1.1.35
Rhea expert-curated reactions2.1.1.35
UniProtKB/Swiss-Prot
Q9UZR7, ATRMA_PYRAB;  Q8U1N4, ATRMA_PYRFU;  O58864, ATRMA_PYRHO;  
Q8IZ69, TRM2A_HUMAN;  Q8BNV1, TRM2A_MOUSE;  A4QP75, TRM2B_DANRE;  
Q96GJ1, TRM2B_HUMAN;  Q8BQJ6, TRM2B_MOUSE;  Q5RFM7, TRM2B_PONAB;  
P33753, TRM2_YEAST;  Q6FBS0, TRMA_ACIAD;  B7H3Q6, TRMA_ACIB3;  
B7I4Y4, TRMA_ACIB5;  B2HYZ7, TRMA_ACIBC;  B0VR22, TRMA_ACIBS;  
A3M4W0, TRMA_ACIBT;  B0VCX5, TRMA_ACIBY;  A3N3R7, TRMA_ACTP2;  
B3GZC6, TRMA_ACTP7;  B0BU06, TRMA_ACTPJ;  A6VLF9, TRMA_ACTSZ;  
A0KQR3, TRMA_AERHH;  A4SHG2, TRMA_AERS4;  C6AQU6, TRMA_AGGAN;  
A8EWU8, TRMA_ALIB4;  Q5E215, TRMA_ALIF1;  B5FCA6, TRMA_ALIFM;  
B6ENT4, TRMA_ALISL;  B4RYR7, TRMA_ALTMD;  Q5P8D0, TRMA_AROAE;  
A1K524, TRMA_AZOSB;  C1DLS8, TRMA_AZOVD;  A7ZDV3, TRMA_CAMC1;  
A7GY40, TRMA_CAMC5;  A0RPL1, TRMA_CAMFF;  A7I332, TRMA_CAMHC;  
A8FLP0, TRMA_CAMJ8;  A7H422, TRMA_CAMJD;  Q9PP92, TRMA_CAMJE;  
A1VZH5, TRMA_CAMJJ;  Q5HUW5, TRMA_CAMJR;  B9KCK3, TRMA_CAMLR;  
B3PJ74, TRMA_CELJU;  Q1QXW4, TRMA_CHRSD;  A8AKV5, TRMA_CITK8;  
Q48A12, TRMA_COLP3;  A7ML95, TRMA_CROS8;  Q47F12, TRMA_DECAR;  
C6CG41, TRMA_DICC1;  A5EXH9, TRMA_DICNV;  A7ZUI5, TRMA_ECO24;  
B7UNU5, TRMA_ECO27;  B7MIA5, TRMA_ECO45;  B7LA67, TRMA_ECO55;  
Q8X723, TRMA_ECO57;  B5Z069, TRMA_ECO5E;  B7NU35, TRMA_ECO7I;  
B7MR93, TRMA_ECO81;  B7M721, TRMA_ECO8A;  C5WBK5, TRMA_ECOBD;  
C6UJK3, TRMA_ECOBR;  C5A0R4, TRMA_ECOBW;  B1XBX6, TRMA_ECODH;  
A8A773, TRMA_ECOHS;  A1AIE7, TRMA_ECOK1;  Q0TA91, TRMA_ECOL5;  
Q8CXW3, TRMA_ECOL6;  B1IVB3, TRMA_ECOLC;  P23003, TRMA_ECOLI;  
B7NFR5, TRMA_ECOLU;  B6I5I3, TRMA_ECOSE;  B1LNS5, TRMA_ECOSM;  
Q1R3U2, TRMA_ECOUT;  C5BC48, TRMA_EDWI9;  A4WG46, TRMA_ENT38;  
B2VGA5, TRMA_ERWT9;  B7LUM8, TRMA_ESCF3;  B8F7Z1, TRMA_GLAP5;  
Q7U339, TRMA_HAEDU;  Q4QM53, TRMA_HAEI8;  A5UDM6, TRMA_HAEIE;  
P31812, TRMA_HAEIN;  Q0I1I7, TRMA_HAES1;  Q7U326, TRMA_HELHP;  
B0UVN9, TRMA_HISS2;  Q31JA4, TRMA_HYDCU;  Q5QVT1, TRMA_IDILO;  
B5XZ11, TRMA_KLEP3;  A6TGE9, TRMA_KLEP7;  Q65PY6, TRMA_MANSM;  
A6W3C7, TRMA_MARMS;  C6C5A0, TRMA_MUSP7;  B9LA97, TRMA_NAUPA;  
Q5F757, TRMA_NEIG1;  B4RN45, TRMA_NEIG2;  P55134, TRMA_NEIGO;  
A9M1Q1, TRMA_NEIM0;  Q9JT82, TRMA_NEIMA;  Q9JYA0, TRMA_NEIMB;  
A1KV88, TRMA_NEIMF;  A6Q2V7, TRMA_NITSB;  Q9CK32, TRMA_PASMU;  
Q6CZB4, TRMA_PECAS;  C6DHQ1, TRMA_PECCP;  Q7MAX6, TRMA_PHOLL;  
Q6LLU2, TRMA_PHOPR;  B4F1H4, TRMA_PROMH;  Q48DT0, TRMA_PSE14;  
Q15NK9, TRMA_PSEA6;  A6VCH5, TRMA_PSEA7;  B7V1D2, TRMA_PSEA8;  
Q02FV3, TRMA_PSEAB;  Q9HV78, TRMA_PSEAE;  Q1I4J8, TRMA_PSEE4;  
Q4K5P2, TRMA_PSEF5;  Q9RHS9, TRMA_PSEFL;  C3K2F6, TRMA_PSEFS;  
A4XQI3, TRMA_PSEMY;  A5W926, TRMA_PSEP1;  Q3K6G9, TRMA_PSEPF;  
B0KHR5, TRMA_PSEPG;  Q88E14, TRMA_PSEPK;  B1J3Q4, TRMA_PSEPW;  
Q87WA0, TRMA_PSESM;  Q3ILM2, TRMA_PSET1;  Q4ZNF5, TRMA_PSEU2;  
A4VI15, TRMA_PSEU5;  A1SSL6, TRMA_PSYIN;  Q21KA1, TRMA_SACD2;  
B5F0V3, TRMA_SALA4;  A9MHG7, TRMA_SALAR;  Q57H88, TRMA_SALCH;  
B5FPX9, TRMA_SALDC;  B5QXR0, TRMA_SALEP;  B5REZ3, TRMA_SALG2;  
B4TCR0, TRMA_SALHS;  B4T0X5, TRMA_SALNS;  Q5PK68, TRMA_SALPA;  
A9N0H5, TRMA_SALPB;  C0Q481, TRMA_SALPC;  B5BJN9, TRMA_SALPK;  
B4TQI0, TRMA_SALSV;  Q8Z313, TRMA_SALTI;  P22038, TRMA_SALTY;  
A8GL74, TRMA_SERP5;  A1S1Z8, TRMA_SHEAM;  B8EBM5, TRMA_SHEB2;  
A3DA80, TRMA_SHEB5;  A6WHQ8, TRMA_SHEB8;  A9KW82, TRMA_SHEB9;  
Q12SP8, TRMA_SHEDO;  Q089S7, TRMA_SHEFN;  B0TMV6, TRMA_SHEHH;  
A3Q962, TRMA_SHELP;  Q8CX51, TRMA_SHEON;  A8GYV6, TRMA_SHEPA;  
A4YB86, TRMA_SHEPC;  B8CH56, TRMA_SHEPW;  A0KRK4, TRMA_SHESA;  
A8G1G7, TRMA_SHESH;  Q0HNV8, TRMA_SHESM;  Q0I0C6, TRMA_SHESR;  
A1RP91, TRMA_SHESW;  B1KN03, TRMA_SHEWM;  B2TWG0, TRMA_SHIB3;  
Q31U23, TRMA_SHIBS;  Q32AE5, TRMA_SHIDS;  Q0SY26, TRMA_SHIF8;  
Q820Z9, TRMA_SHIFL;  Q3YV11, TRMA_SHISS;  Q2NQZ6, TRMA_SODGM;  
Q30RT5, TRMA_SULDN;  A6QBC0, TRMA_SULNB;  C5BTY4, TRMA_TERTT;  
C4L9A7, TRMA_TOLAT;  B7VM88, TRMA_VIBA3;  A7MXY6, TRMA_VIBC1;  
A5F4M4, TRMA_VIBC3;  Q9KVJ0, TRMA_VIBCH;  C3LPZ5, TRMA_VIBCM;  
Q87KN8, TRMA_VIBPA;  Q8DD43, TRMA_VIBVU;  Q7MQ79, TRMA_VIBVY;  
Q7M7T6, TRMA_WOLSU;  A1JI40, TRMA_YERE8;  A7FD13, TRMA_YERP3;  
Q1CBU2, TRMA_YERPA;  B2JZF7, TRMA_YERPB;  Q8ZAA0, TRMA_YERPE;  
A9R6N8, TRMA_YERPG;  Q1CNP1, TRMA_YERPN;  A4TRG1, TRMA_YERPP;  
Q66G58, TRMA_YERPS;  B1JQ46, TRMA_YERPY;  Q09833, YAD7_SCHPO;  

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