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ENZYME

ENZYME entry: EC 2.1.1.35

Accepted Name
tRNA (uracil(54)-C(5))-methyltransferase
Alternative Name(s)
5-methyluridine(54) tRNA methyltransferase
m(5)U(54)-methyltransferase
m5U-methyltransferase
ribothymidyl synthase
RUMT
transfer RNA uracil(54) 5-methyltransferase
transfer RNA uracil(54) methylase
transfer RNA uracil 5-methyltransferase
transfer RNA uracil methylase
tRNA:m(5)U(54)-methyltransferase
tRNA(m(5)U(54))methyltransferase
tRNA(uracil-54,C(5))-methyltransferase
tRNA uracil(54) 5-methyltransferase
tRNA uracil 5-methyltransferase
Reaction catalysed
S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine
Comment(s)
Unlike this enzyme, EC 2.1.1.74 uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54.
Cross-references
BRENDA2.1.1.35
EC2PDB2.1.1.35
ExplorEnz2.1.1.35
PRIAM enzyme-specific profiles2.1.1.35
KEGG Ligand Database for Enzyme Nomenclature2.1.1.35
IUBMB Enzyme Nomenclature2.1.1.35
IntEnz2.1.1.35
MEDLINEFind literature relating to 2.1.1.35
MetaCyc2.1.1.35
Rhea expert-curated reactions2.1.1.35
UniProtKB/Swiss-Prot
Q9UZR7, ATRMA_PYRABQ8U1N4, ATRMA_PYRFUO58864, ATRMA_PYRHO
Q8IZ69, TRM2A_HUMANQ8BNV1, TRM2A_MOUSEA4QP75, TRM2B_DANRE
Q96GJ1, TRM2B_HUMANQ8BQJ6, TRM2B_MOUSEQ5RFM7, TRM2B_PONAB
P33753, TRM2_YEASTQ6FBS0, TRMA_ACIADB7H3Q6, TRMA_ACIB3
B7I4Y4, TRMA_ACIB5B2HYZ7, TRMA_ACIBCB0VR22, TRMA_ACIBS
A3M4W0, TRMA_ACIBTB0VCX5, TRMA_ACIBYA3N3R7, TRMA_ACTP2
B3GZC6, TRMA_ACTP7B0BU06, TRMA_ACTPJA6VLF9, TRMA_ACTSZ
A0KQR3, TRMA_AERHHA4SHG2, TRMA_AERS4C6AQU6, TRMA_AGGAN
A8EWU8, TRMA_ALIB4Q5E215, TRMA_ALIF1B5FCA6, TRMA_ALIFM
B6ENT4, TRMA_ALISLB4RYR7, TRMA_ALTMDQ5P8D0, TRMA_AROAE
A1K524, TRMA_AZOSBC1DLS8, TRMA_AZOVDA7ZDV3, TRMA_CAMC1
A7GY40, TRMA_CAMC5A0RPL1, TRMA_CAMFFA7I332, TRMA_CAMHC
A8FLP0, TRMA_CAMJ8A7H422, TRMA_CAMJDQ9PP92, TRMA_CAMJE
A1VZH5, TRMA_CAMJJQ5HUW5, TRMA_CAMJRB9KCK3, TRMA_CAMLR
B3PJ74, TRMA_CELJUQ1QXW4, TRMA_CHRSDA8AKV5, TRMA_CITK8
Q48A12, TRMA_COLP3A7ML95, TRMA_CROS8Q47F12, TRMA_DECAR
C6CG41, TRMA_DICC1A5EXH9, TRMA_DICNVA7ZUI5, TRMA_ECO24
B7UNU5, TRMA_ECO27B7MIA5, TRMA_ECO45B7LA67, TRMA_ECO55
Q8X723, TRMA_ECO57B5Z069, TRMA_ECO5EB7NU35, TRMA_ECO7I
B7MR93, TRMA_ECO81B7M721, TRMA_ECO8AC5WBK5, TRMA_ECOBD
C6UJK3, TRMA_ECOBRC5A0R4, TRMA_ECOBWB1XBX6, TRMA_ECODH
A8A773, TRMA_ECOHSA1AIE7, TRMA_ECOK1Q0TA91, TRMA_ECOL5
Q8CXW3, TRMA_ECOL6B1IVB3, TRMA_ECOLCP23003, TRMA_ECOLI
B7NFR5, TRMA_ECOLUB6I5I3, TRMA_ECOSEB1LNS5, TRMA_ECOSM
Q1R3U2, TRMA_ECOUTC5BC48, TRMA_EDWI9A4WG46, TRMA_ENT38
B2VGA5, TRMA_ERWT9B7LUM8, TRMA_ESCF3B8F7Z1, TRMA_GLAP5
Q7U339, TRMA_HAEDUQ4QM53, TRMA_HAEI8A5UDM6, TRMA_HAEIE
P31812, TRMA_HAEINQ7U326, TRMA_HELHPQ0I1I7, TRMA_HISS1
B0UVN9, TRMA_HISS2Q31JA4, TRMA_HYDCUQ5QVT1, TRMA_IDILO
B5XZ11, TRMA_KLEP3A6TGE9, TRMA_KLEP7Q65PY6, TRMA_MANSM
A6W3C7, TRMA_MARMSC6C5A0, TRMA_MUSP7B9LA97, TRMA_NAUPA
Q5F757, TRMA_NEIG1B4RN45, TRMA_NEIG2P55134, TRMA_NEIGO
A9M1Q1, TRMA_NEIM0Q9JT82, TRMA_NEIMAQ9JYA0, TRMA_NEIMB
A1KV88, TRMA_NEIMFA6Q2V7, TRMA_NITSBQ9CK32, TRMA_PASMU
Q6CZB4, TRMA_PECASC6DHQ1, TRMA_PECCPQ7MAX6, TRMA_PHOLL
Q6LLU2, TRMA_PHOPRB4F1H4, TRMA_PROMHQ48DT0, TRMA_PSE14
Q15NK9, TRMA_PSEA6A6VCH5, TRMA_PSEA7B7V1D2, TRMA_PSEA8
Q02FV3, TRMA_PSEABQ9HV78, TRMA_PSEAEQ1I4J8, TRMA_PSEE4
Q4K5P2, TRMA_PSEF5Q9RHS9, TRMA_PSEFLC3K2F6, TRMA_PSEFS
A4XQI3, TRMA_PSEMYA5W926, TRMA_PSEP1Q3K6G9, TRMA_PSEPF
B0KHR5, TRMA_PSEPGQ88E14, TRMA_PSEPKB1J3Q4, TRMA_PSEPW
Q87WA0, TRMA_PSESMQ3ILM2, TRMA_PSET1Q4ZNF5, TRMA_PSEU2
A1SSL6, TRMA_PSYINQ21KA1, TRMA_SACD2B5F0V3, TRMA_SALA4
A9MHG7, TRMA_SALARQ57H88, TRMA_SALCHB5FPX9, TRMA_SALDC
B5QXR0, TRMA_SALEPB5REZ3, TRMA_SALG2B4TCR0, TRMA_SALHS
B4T0X5, TRMA_SALNSQ5PK68, TRMA_SALPAA9N0H5, TRMA_SALPB
C0Q481, TRMA_SALPCB5BJN9, TRMA_SALPKB4TQI0, TRMA_SALSV
Q8Z313, TRMA_SALTIP22038, TRMA_SALTYA8GL74, TRMA_SERP5
A1S1Z8, TRMA_SHEAMB8EBM5, TRMA_SHEB2A3DA80, TRMA_SHEB5
A6WHQ8, TRMA_SHEB8A9KW82, TRMA_SHEB9Q12SP8, TRMA_SHEDO
Q089S7, TRMA_SHEFNB0TMV6, TRMA_SHEHHA3Q962, TRMA_SHELP
Q8CX51, TRMA_SHEONA8GYV6, TRMA_SHEPAA4YB86, TRMA_SHEPC
B8CH56, TRMA_SHEPWA0KRK4, TRMA_SHESAA8G1G7, TRMA_SHESH
Q0HNV8, TRMA_SHESMQ0I0C6, TRMA_SHESRA1RP91, TRMA_SHESW
B1KN03, TRMA_SHEWMB2TWG0, TRMA_SHIB3Q31U23, TRMA_SHIBS
Q32AE5, TRMA_SHIDSQ0SY26, TRMA_SHIF8Q820Z9, TRMA_SHIFL
Q3YV11, TRMA_SHISSQ2NQZ6, TRMA_SODGMA4VI15, TRMA_STUS1
Q30RT5, TRMA_SULDNA6QBC0, TRMA_SULNBC5BTY4, TRMA_TERTT
C4L9A7, TRMA_TOLATB7VM88, TRMA_VIBA3A7MXY6, TRMA_VIBC1
A5F4M4, TRMA_VIBC3Q9KVJ0, TRMA_VIBCHC3LPZ5, TRMA_VIBCM
Q87KN8, TRMA_VIBPAQ8DD43, TRMA_VIBVUQ7MQ79, TRMA_VIBVY
Q7M7T6, TRMA_WOLSUA1JI40, TRMA_YERE8A7FD13, TRMA_YERP3
Q1CBU2, TRMA_YERPAB2JZF7, TRMA_YERPBQ8ZAA0, TRMA_YERPE
A9R6N8, TRMA_YERPGQ1CNP1, TRMA_YERPNA4TRG1, TRMA_YERPP
Q66G58, TRMA_YERPSB1JQ46, TRMA_YERPYQ09833, YAD7_SCHPO

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-