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ENZYME

ENZYME entry: EC 2.1.1.74

Accepted Name
methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase [NAD(P)H-oxidizing]
Alternative Name(s)
folate/FAD-dependent tRNA T54 methyltransferase
folate-dependent ribothymidyl synthase
Reaction catalysed
  • (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)
  • (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)
Comment(s)
  • A flavoprotein (FAD).
  • Up to 25% of the bases in mature tRNA are post-translationally modified or hypermodified.
  • One almost universal post-translational modification is the conversion of U(54) into ribothymidine in the TPsiC loop, and this modification is found in most species studied to date.
  • Unlike this enzyme, which uses 5,10-methylenetetrahydrofolate and NAD(P)H to supply the atoms for methylation of U(54), EC 2.1.1.35 uses S-adenosyl-L-methionine.
  • Formerly EC 2.1.2.12.
Cross-references
BRENDA2.1.1.74
EC2PDB2.1.1.74
ExplorEnz2.1.1.74
PRIAM enzyme-specific profiles2.1.1.74
KEGG Ligand Database for Enzyme Nomenclature2.1.1.74
IUBMB Enzyme Nomenclature2.1.1.74
IntEnz2.1.1.74
MEDLINEFind literature relating to 2.1.1.74
MetaCyc2.1.1.74
Rhea expert-curated reactions2.1.1.74
UniProtKB/Swiss-Prot
Q6F1M4, TMFO1_MESFLQ2SS13, TMFO1_MYCCTQ6MTM6, TMFO1_MYCMS
Q6F0T3, TMFO2_MESFLQ2SRN2, TMFO2_MYCCTQ6MTB4, TMFO2_MYCMS
B0C6V8, TRMFO_ACAM1A3DCM0, TRMFO_ACET2A9NHD0, TRMFO_ACHLI
Q8UET6, TRMFO_AGRFCQ5WFP8, TRMFO_ALKCKB8JES4, TRMFO_ANAD2
Q2ILE0, TRMFO_ANADEA7HDU6, TRMFO_ANADFB4UII2, TRMFO_ANASK
B7GGC8, TRMFO_ANOFWO66913, TRMFO_AQUAEA8ID68, TRMFO_AZOC5
C3P5N4, TRMFO_BACAAC3L795, TRMFO_BACACA0RHK5, TRMFO_BACAH
Q81WK3, TRMFO_BACANB7JJB0, TRMFO_BACC0Q732N8, TRMFO_BACC1
B7IUJ1, TRMFO_BACC2C1EP56, TRMFO_BACC3B7HDV5, TRMFO_BACC4
B7HLG5, TRMFO_BACC7A7GRG2, TRMFO_BACCNB9IVC1, TRMFO_BACCQ
Q819X4, TRMFO_BACCRQ636J4, TRMFO_BACCZQ6HEY3, TRMFO_BACHK
Q65JN6, TRMFO_BACLDA9VT70, TRMFO_BACMKA8FD77, TRMFO_BACP2
P39815, TRMFO_BACSUA7Z4N3, TRMFO_BACVZA1USB2, TRMFO_BARBK
Q6G3Y9, TRMFO_BARHEA9ISB8, TRMFO_BART1Q6MHW5, TRMFO_BDEBA
B2IGU6, TRMFO_BEII9Q89L21, TRMFO_BRADUA5EJU4, TRMFO_BRASB
A4YV54, TRMFO_BRASOC0ZFA9, TRMFO_BREBNQ2YNL7, TRMFO_BRUA2
A6X1E3, TRMFO_BRUA4Q57DL3, TRMFO_BRUABA9MAR7, TRMFO_BRUC2
P64232, TRMFO_BRUMEA5VQ76, TRMFO_BRUO2B0CLM0, TRMFO_BRUSI
P64233, TRMFO_BRUSUB9MM32, TRMFO_CALBDA4XIW8, TRMFO_CALS8
Q3AB71, TRMFO_CARHZB0T866, TRMFO_CAUSKQ9A566, TRMFO_CAUVC
A3PJ80, TRMFO_CERS1Q3J349, TRMFO_CERS4A4WRQ2, TRMFO_CERS5
B9KRK8, TRMFO_CERSKQ11HD9, TRMFO_CHESBB5EHR5, TRMFO_CITBB
B5Y8G1, TRMFO_COPPDB1WR77, TRMFO_CROS5Q1J148, TRMFO_DEIGD
Q9RXU7, TRMFO_DEIRAB1I258, TRMFO_DESAPQ24UF0, TRMFO_DESHY
Q6ALS7, TRMFO_DESPSA4J5Z8, TRMFO_DESRMQ729K0, TRMFO_DESVH
A1VBW6, TRMFO_DESVVB5YFC6, TRMFO_DICT6B8E2F5, TRMFO_DICTD
A8LK18, TRMFO_DINSHQ834K1, TRMFO_ENTFAQ2NAC8, TRMFO_ERYLH
B1YIB2, TRMFO_EXIS2C4L614, TRMFO_EXISAA7HL16, TRMFO_FERNB
Q8REM9, TRMFO_FUSNNB9M5T8, TRMFO_GEODFQ39X89, TRMFO_GEOMG
Q74A44, TRMFO_GEOSLC6E557, TRMFO_GEOSMA5G7S3, TRMFO_GEOUR
Q7NFC3, TRMFO_GLOVIQ9KA24, TRMFO_HALH5B0TH93, TRMFO_HELMI
B4U7L4, TRMFO_HYDS0Q0BYJ6, TRMFO_HYPNAQ28PE7, TRMFO_JANSC
Q1IHM1, TRMFO_KORVEQ5FKE1, TRMFO_LACACQ1G9V1, TRMFO_LACDA
Q04A02, TRMFO_LACDBQ043R6, TRMFO_LACGAA8YV48, TRMFO_LACH4
Q74JJ8, TRMFO_LACJOQ9CG79, TRMFO_LACLAA2RKQ0, TRMFO_LACLM
Q02YZ3, TRMFO_LACLSQ039E2, TRMFO_LACP3Q88W23, TRMFO_LACPL
Q38WZ1, TRMFO_LATSSQ1MQ25, TRMFO_LAWIPQ1WU04, TRMFO_LIGS1
Q92C76, TRMFO_LISINQ720E5, TRMFO_LISMFQ8Y7K1, TRMFO_LISMO
A0AI79, TRMFO_LISW6B1HQJ3, TRMFO_LYSSCA0LDC6, TRMFO_MAGMM
Q2W4D9, TRMFO_MAGSAQ0ANF3, TRMFO_MARMMA9VXT4, TRMFO_METEP
B1ZES7, TRMFO_METPBB1M5H7, TRMFO_METRJB0UI96, TRMFO_METS4
B0JFX8, TRMFO_MICANQ2RJP8, TRMFO_MOOTAA5IXT6, TRMFO_MYCAP
Q9S449, TRMFO_MYXXDB2A334, TRMFO_NATTJQ1QMC9, TRMFO_NITHX
Q3SRR6, TRMFO_NITWNQ8YNJ4, TRMFO_NOSS1Q2G718, TRMFO_NOVAD
Q312C5, TRMFO_OLEA2A1B9F0, TRMFO_PARDPA7HXL5, TRMFO_PARL1
Q7U7T2, TRMFO_PARMWA1ALD8, TRMFO_PELPDA5D2W5, TRMFO_PELTS
C0QTE2, TRMFO_PERMHB4RDH0, TRMFO_PHEZHA3PDM1, TRMFO_PROM0
A2C3G4, TRMFO_PROM1A8G5I6, TRMFO_PROM2A2C8E1, TRMFO_PROM3
A9BEK6, TRMFO_PROM4A2BXA3, TRMFO_PROM5Q31AA9, TRMFO_PROM9
Q7VD04, TRMFO_PROMAQ7TUW5, TRMFO_PROMMQ7TU75, TRMFO_PROMP
A2BRU5, TRMFO_PROMSQ46K52, TRMFO_PROMTA8F516, TRMFO_PSELT
Q2K957, TRMFO_RHIECQ1MHL2, TRMFO_RHIL3Q98LE1, TRMFO_RHILO
Q92Q15, TRMFO_RHIMEA5V4M8, TRMFO_RHIWRO68141, TRMFO_RHOCB
Q2IWI0, TRMFO_RHOP2Q07MJ4, TRMFO_RHOP5Q6N5Z1, TRMFO_RHOPA
Q213W6, TRMFO_RHOPBQ136I8, TRMFO_RHOPSQ2RTI8, TRMFO_RHORT
Q166D3, TRMFO_ROSDOQ1ATM0, TRMFO_RUBXDQ5LST0, TRMFO_RUEPO
Q1GGU2, TRMFO_RUESTA6U8P9, TRMFO_SINMWQ02C58, TRMFO_SOLUE
A9FRC1, TRMFO_SORC5Q1GTZ7, TRMFO_SPHALA7X1M6, TRMFO_STAA1
A6U169, TRMFO_STAA2Q2FHI7, TRMFO_STAA3Q2FZ31, TRMFO_STAA8
A5ISD5, TRMFO_STAA9Q2YXL7, TRMFO_STAABQ5HGI1, TRMFO_STAAC
A6QGF1, TRMFO_STAAEP64234, TRMFO_STAAMP64235, TRMFO_STAAN
Q6GHI4, TRMFO_STAARQ6G9W2, TRMFO_STAASA8Z3T1, TRMFO_STAAT
P64236, TRMFO_STAAWB9DPG3, TRMFO_STACTQ5HPU1, TRMFO_STAEQ
Q8CPH2, TRMFO_STAESQ4L5V3, TRMFO_STAHJQ49X36, TRMFO_STAS1
Q3K1B8, TRMFO_STRA1Q8E5M6, TRMFO_STRA3Q8DZX5, TRMFO_STRA5
C0M6C7, TRMFO_STRE4A8AXH0, TRMFO_STRGCP05428, TRMFO_STRMU
Q99ZL9, TRMFO_STRP1Q04KY2, TRMFO_STRP2P0DB36, TRMFO_STRP3
B5E446, TRMFO_STRP4Q5XC46, TRMFO_STRP6C1C6S2, TRMFO_STRP7
Q8P106, TRMFO_STRP8Q1JBP0, TRMFO_STRPBQ1JLM2, TRMFO_STRPC
Q1JGS2, TRMFO_STRPDQ1J6J1, TRMFO_STRPFA2REF7, TRMFO_STRPG
B1IBA6, TRMFO_STRPIB8ZP43, TRMFO_STRPJQ48TI1, TRMFO_STRPM
Q97R84, TRMFO_STRPNP0DB37, TRMFO_STRPQB2IP98, TRMFO_STRPS
Q8DQ51, TRMFO_STRR6A4W125, TRMFO_STRS2C0MFF9, TRMFO_STRS7
A3CN32, TRMFO_STRSVA4VUS8, TRMFO_STRSYQ5M014, TRMFO_STRT1
Q5M4M7, TRMFO_STRT2Q03KX0, TRMFO_STRTDB9DS62, TRMFO_STRU0
C1CDT9, TRMFO_STRZJC1CK27, TRMFO_STRZPC1CRV5, TRMFO_STRZT
B2V9U2, TRMFO_SULSYQ67PC6, TRMFO_SYMTHQ2LT41, TRMFO_SYNAS
Q3A7H9, TRMFO_SYNC1Q31NM4, TRMFO_SYNE7Q2JRF7, TRMFO_SYNJA
Q2JQ64, TRMFO_SYNJBB1XK17, TRMFO_SYNP2Q5N5J0, TRMFO_SYNP6
A5GLJ3, TRMFO_SYNPWA5GU85, TRMFO_SYNR3Q0IB24, TRMFO_SYNS3
Q3AX63, TRMFO_SYNS9Q3AIZ7, TRMFO_SYNSCQ0AYP4, TRMFO_SYNWW
Q55692, TRMFO_SYNY3B7IFU6, TRMFO_THEABA6LJK8, TRMFO_THEM4
Q9WZJ3, TRMFO_THEMAB9KAP3, TRMFO_THENNA5IJ51, TRMFO_THEP1
B1L7X2, TRMFO_THESQQ72IQ5, TRMFO_THET2Q5SID2, TRMFO_THET8
P59109, TRMFO_THEVBQ3MA89, TRMFO_TRIV2A7INE1, TRMFO_XANP2
Q5NPP5, TRMFO_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-