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ENZYME entry: EC 2.1.1.350

Accepted Name
Menaquinone C(8)-methyltransferase.
Reaction catalysed
  • 2 S-adenosyl-L-methionine + a menaquinone + reduced flavodoxin <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + an 8-methylmenaquinone + oxidized flavodoxin
  • 2 S-adenosyl-L-methionine + a 2-demethylmenaquinone + reduced flavodoxin <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + oxidized flavodoxin
Comment(s)
The enzyme, found in a wide range of bacteria and archaea, is a radical SAM (AdoMet) enzyme that utilizes two molecules of S-adenosyl-L-methionine, one as the methyl group donor, and one for the creation of a 5'-deoxyadenosine radical that drives the reaction forward.
Cross-references
BRENDA2.1.1.350
EC2PDB2.1.1.350
ExplorEnz2.1.1.350
PRIAM enzyme-specific profiles2.1.1.350
KEGG Ligand Database for Enzyme Nomenclature2.1.1.350
IUBMB Enzyme Nomenclature2.1.1.350
IntEnz2.1.1.350
MEDLINEFind literature relating to 2.1.1.350
MetaCyc2.1.1.350
Rhea expert-curated reactions2.1.1.350

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-