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ENZYME entry: EC 2.1.1.360

Accepted Name
[Histone H3]-lysine(79) N-trimethyltransferase.
Reaction catalysed
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine(79) <=> 3 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(79)
Comment(s)
  • The enzyme successively methylates the L-lysine(79) residue of histone H3 (H3K79), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • This is the only known methylation event of a lysine residue within the core region of a histone, as all other such modifications occur at the tail.
  • Formerly EC 2.1.1.34.
Cross-references
BRENDA2.1.1.360
EC2PDB2.1.1.360
ExplorEnz2.1.1.360
PRIAM enzyme-specific profiles2.1.1.360
KEGG Ligand Database for Enzyme Nomenclature2.1.1.360
IUBMB Enzyme Nomenclature2.1.1.360
IntEnz2.1.1.360
MEDLINEFind literature relating to 2.1.1.360
MetaCyc2.1.1.360

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