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ENZYME entry: EC 2.1.1.362
Accepted Name |
[histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
|
Reaction catalysed |
N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine |
Comment(s) |
- This entry describes a group of enzymes that catalyze a single
methylation of monomethylated lysine(20) of histone H4 (H4K20m1,
generated by EC 2.1.1.361), forming the dimethylated form.
- This modification is broadly distributed across the genome and is
likely important for general chromatin-mediated processes.
- The double-methylated form of lysine(20) in histone H4 is the most
abundant methylation state of this residue and is found on ~80% of
all histone H4 molecules.
- Full activity of the enzyme requires that the lysine at position 9 of
histone H3 is trimethylated.
|
Cross-references |
BRENDA | 2.1.1.362 |
EC2PDB | 2.1.1.362 |
ExplorEnz | 2.1.1.362 |
PRIAM enzyme-specific profiles | 2.1.1.362 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.362 |
IUBMB Enzyme Nomenclature | 2.1.1.362 |
IntEnz | 2.1.1.362 |
MEDLINE | Find literature relating to 2.1.1.362 |
MetaCyc | 2.1.1.362 |
Rhea expert-curated reactions | 2.1.1.362 |
UniProtKB/Swiss-Prot |
Q29RP8, KMT5B_BOVIN; | Q5U3H2, KMT5B_DANRE; | Q4FZB7, KMT5B_HUMAN; |
Q3U8K7, KMT5B_MOUSE; | P0C2N5, KMT5B_RAT; | Q86Y97, KMT5C_HUMAN; |
Q6Q783, KMT5C_MOUSE; | P0C2N6, KMT5C_RAT; | A0JMZ4, KMT5C_XENLA; |
Q6GP17, KT5BA_XENLA; | Q5RJX8, KT5BB_XENLA; | Q6P2A1, PRDM9_DANRE; |
Q9NQV7, PRDM9_HUMAN; | Q96EQ9, PRDM9_MOUSE; | P0C6Y7, PRDM9_RAT; |
A8WTV9, SUV42_CAEBR; | Q09265, SUV42_CAEEL; | Q9W5E0, SUV42_DROME; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-