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ENZYME

ENZYME entry: EC 2.1.1.362

Accepted Name
[histone H4]-N-methyl-L-lysine(20) N-methyltransferase
Reaction catalysed
N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes a group of enzymes that catalyze a single methylation of monomethylated lysine(20) of histone H4 (H4K20m1, generated by EC 2.1.1.361), forming the dimethylated form.
  • This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes.
  • The double-methylated form of lysine(20) in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules.
  • Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.
Cross-references
BRENDA2.1.1.362
EC2PDB2.1.1.362
ExplorEnz2.1.1.362
PRIAM enzyme-specific profiles2.1.1.362
KEGG Ligand Database for Enzyme Nomenclature2.1.1.362
IUBMB Enzyme Nomenclature2.1.1.362
IntEnz2.1.1.362
MEDLINEFind literature relating to 2.1.1.362
MetaCyc2.1.1.362
Rhea expert-curated reactions2.1.1.362
UniProtKB/Swiss-Prot
Q29RP8, KMT5B_BOVINQ5U3H2, KMT5B_DANREQ4FZB7, KMT5B_HUMAN
Q3U8K7, KMT5B_MOUSEP0C2N5, KMT5B_RATQ86Y97, KMT5C_HUMAN
Q6Q783, KMT5C_MOUSEP0C2N6, KMT5C_RATA0JMZ4, KMT5C_XENLA
Q6GP17, KT5BA_XENLAQ5RJX8, KT5BB_XENLAQ6P2A1, PRDM9_DANRE
Q9NQV7, PRDM9_HUMANQ96EQ9, PRDM9_MOUSEP0C6Y7, PRDM9_RAT
A8WTV9, SUV42_CAEBRQ09265, SUV42_CAEELQ9W5E0, SUV42_DROME

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