ENZYME entry: EC 2.1.1.362
| Accepted Name |
|---|
| [Histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
|
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + a [histone H4]-N(6)-methyl-L-lysine(20) <=> S-adenosyl-L-homocysteine + a [histone H4]-N(6),N(6)-dimethyl-L-lysine(20) |
| Comment(s) |
|---|
- This entry describes a group of enzymes that catalyze a single
methylation of monomethylated lysine(20) of histone H4 (H4K20m1,
generated by EC 2.1.1.361), forming the dimethylated form.
- This modification is broadly distributed across the genome and is
likely important for general chromatin-mediated processes.
- The double-methylated form of lysine(20) in histone H4 is the most
abundant methylation state of this residue and is found on ~80% of
all histone H4 molecules.
- Full activity of the enzyme requires that the lysine at position 9 of
histone H3 is trimethylated.
- Formerly EC 2.1.1.34.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.362 |
| EC2PDB | 2.1.1.362 |
| ExplorEnz | 2.1.1.362 |
| PRIAM enzyme-specific profiles | 2.1.1.362 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.362 |
| IUBMB Enzyme Nomenclature | 2.1.1.362 |
| IntEnz | 2.1.1.362 |
| MEDLINE | Find literature relating to 2.1.1.362 |
| MetaCyc | 2.1.1.362 |
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