ENZYME entry: EC 2.1.1.361
| Accepted Name |
|---|
| [Histone H4]-lysine(20) N-methyltransferase.
|
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + a [histone H4]-L-lysine(20) <=> S-adenosyl-L-homocysteine + a [histone H4]-N(6)-methyl-L-lysine(20) |
| Comment(s) |
|---|
- The enzyme catalyzes the monomethylation of the L-lysine(20) residue
of histone H4 (H4K20).
- This event is usually followed by further methylation by
EC 2.1.1.362, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
- This enzyme plays a pivotal role in DNA replication.
- Activity is high during the G2 and M phases, but declines
significantly during G1 and S phases.
- Mutations in the enzyme have severe consequences, including DNA
double-strand breaks, activation of DNA damage checkpoints, defective
cell cycle progression, and reduced cell proliferation.
- Formerly EC 2.1.1.34.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.361 |
| EC2PDB | 2.1.1.361 |
| ExplorEnz | 2.1.1.361 |
| PRIAM enzyme-specific profiles | 2.1.1.361 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.361 |
| IUBMB Enzyme Nomenclature | 2.1.1.361 |
| IntEnz | 2.1.1.361 |
| MEDLINE | Find literature relating to 2.1.1.361 |
| MetaCyc | 2.1.1.361 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-