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ENZYME

ENZYME entry: EC 2.1.1.361

Accepted Name
[histone H4]-lysine(20) N-methyltransferase
Reaction catalysed
L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme catalyzes the monomethylation of the L-lysine(20) residue of histone H4 (H4K20).
  • This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
  • This enzyme plays a pivotal role in DNA replication.
  • Activity is high during the G2 and M phases, but declines significantly during G1 and S phases.
  • Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.
Cross-references
BRENDA2.1.1.361
EC2PDB2.1.1.361
ExplorEnz2.1.1.361
PRIAM enzyme-specific profiles2.1.1.361
KEGG Ligand Database for Enzyme Nomenclature2.1.1.361
IUBMB Enzyme Nomenclature2.1.1.361
IntEnz2.1.1.361
MEDLINEFind literature relating to 2.1.1.361
MetaCyc2.1.1.361
Rhea expert-curated reactions2.1.1.361
UniProtKB/Swiss-Prot
Q2YDJ8, KMT5A_BOVINQ9VFK6, KMT5A_DROMEQ297V5, KMT5A_DROPS
Q9NQR1, KMT5A_HUMANQ2YDW7, KMT5A_MOUSEQ0V9E9, KMT5A_XENTR
Q29RP8, KMT5B_BOVINQ5U3H2, KMT5B_DANREQ4FZB7, KMT5B_HUMAN
Q3U8K7, KMT5B_MOUSEP0C2N5, KMT5B_RATQ86Y97, KMT5C_HUMAN
Q6Q783, KMT5C_MOUSEP0C2N6, KMT5C_RATA0JMZ4, KMT5C_XENLA
Q071E0, KT5AA_DANREQ08AY6, KT5AA_XENLAQ498E6, KT5AB_XENLA
Q6GP17, KT5BA_XENLAQ5RJX8, KT5BB_XENLAA6QPM3, PRDM6_BOVIN
Q9NQX0, PRDM6_HUMANQ3UZD5, PRDM6_MOUSEQ6P2A1, PRDM9_DANRE
Q9NQV7, PRDM9_HUMANQ96EQ9, PRDM9_MOUSEP0C6Y7, PRDM9_RAT
Q22795, SET1_CAEELQ9W5E0, SUV42_DROME

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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