- The enzyme catalyzes the monomethylation of the L-lysine(20) residue
of histone H4 (H4K20).
- This event is usually followed by further methylation by
EC 2.1.1.362, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
- This enzyme plays a pivotal role in DNA replication.
- Activity is high during the G2 and M phases, but declines
significantly during G1 and S phases.
- Mutations in the enzyme have severe consequences, including DNA
double-strand breaks, activation of DNA damage checkpoints, defective
cell cycle progression, and reduced cell proliferation.
- Formerly EC 2.1.1.43.
|
| UniProtKB/Swiss-Prot |
| Q2YDJ8, KMT5A_BOVIN; | Q9VFK6, KMT5A_DROME; | Q297V5, KMT5A_DROPS; |
| Q9NQR1, KMT5A_HUMAN; | Q2YDW7, KMT5A_MOUSE; | Q0V9E9, KMT5A_XENTR; |
| Q29RP8, KMT5B_BOVIN; | Q5U3H2, KMT5B_DANRE; | Q4FZB7, KMT5B_HUMAN; |
| Q3U8K7, KMT5B_MOUSE; | P0C2N5, KMT5B_RAT; | Q86Y97, KMT5C_HUMAN; |
| Q6Q783, KMT5C_MOUSE; | P0C2N6, KMT5C_RAT; | A0JMZ4, KMT5C_XENLA; |
| Q071E0, KT5AA_DANRE; | Q08AY6, KT5AA_XENLA; | Q498E6, KT5AB_XENLA; |
| Q6GP17, KT5BA_XENLA; | Q5RJX8, KT5BB_XENLA; | A6QPM3, PRDM6_BOVIN; |
| Q9NQX0, PRDM6_HUMAN; | Q3UZD5, PRDM6_MOUSE; | Q6P2A1, PRDM9_DANRE; |
| Q9NQV7, PRDM9_HUMAN; | Q96EQ9, PRDM9_MOUSE; | P0C6Y7, PRDM9_RAT; |
| Q22795, SET1_CAEEL; | Q4X1W8, SET9_ASPFU; | Q2TZH4, SET9_ASPOR; |
| Q0C9E6, SET9_ASPTN; | Q2H8D5, SET9_CHAGB; | Q1E9C0, SET9_COCIM; |
| Q5AZY3, SET9_EMENI; | Q4I8C9, SET9_GIBZE; | Q7SBJ9, SET9_NEUCR; |
| Q0U3A4, SET9_PHANO; | Q9USK2, SET9_SCHPO; | Q6C519, SET9_YARLI; |
| Q9W5E0, SUV42_DROME; |
|