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ENZYME entry: EC 2.1.1.361

Accepted Name
[Histone H4]-lysine(20) N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a [histone H4]-L-lysine(20) <=> S-adenosyl-L-homocysteine + a [histone H4]-N(6)-methyl-L-lysine(20)
Comment(s)
  • The enzyme catalyzes the monomethylation of the L-lysine(20) residue of histone H4 (H4K20).
  • This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
  • This enzyme plays a pivotal role in DNA replication.
  • Activity is high during the G2 and M phases, but declines significantly during G1 and S phases.
  • Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.
  • Formerly EC 2.1.1.34.
Cross-references
BRENDA2.1.1.361
EC2PDB2.1.1.361
ExplorEnz2.1.1.361
PRIAM enzyme-specific profiles2.1.1.361
KEGG Ligand Database for Enzyme Nomenclature2.1.1.361
IUBMB Enzyme Nomenclature2.1.1.361
IntEnz2.1.1.361
MEDLINEFind literature relating to 2.1.1.361
MetaCyc2.1.1.361

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