Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.361

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.361
Accepted Name
[histone H4]-lysine(20) N-methyltransferase
Reaction catalysed
L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzyme catalyzes the monomethylation of the L-lysine(20) residue of histone H4 (H4K20).
  • This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
  • This enzyme plays a pivotal role in DNA replication.
  • Activity is high during the G2 and M phases, but declines significantly during G1 and S phases.
  • Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.
Cross-references
BRENDA2.1.1.361
EC2PDB2.1.1.361
ExplorEnz2.1.1.361
KEGG Ligand Database for Enzyme Nomenclature2.1.1.361
IUBMB Enzyme Nomenclature2.1.1.361
MEDLINEFind literature relating to 2.1.1.361
MetaCyc2.1.1.361
Rhea expert-curated reactions2.1.1.361
UniProtKB/Swiss-Prot
Q2YDJ8, KMT5A_BOVINQ22795, KMT5A_CAEELQ9VFK6, KMT5A_DROME
Q297V5, KMT5A_DROPSQ9NQR1, KMT5A_HUMANQ2YDW7, KMT5A_MOUSE
Q0V9E9, KMT5A_XENTRQ29RP8, KMT5B_BOVINQ5U3H2, KMT5B_DANRE
Q4FZB7, KMT5B_HUMANQ3U8K7, KMT5B_MOUSEP0C2N5, KMT5B_RAT
Q86Y97, KMT5C_HUMANQ6Q783, KMT5C_MOUSEP0C2N6, KMT5C_RAT
A0JMZ4, KMT5C_XENLAQ071E0, KT5AA_DANREQ08AY6, KT5AA_XENLA
Q498E6, KT5AB_XENLAQ6GP17, KT5BA_XENLAQ5RJX8, KT5BB_XENLA
A6QPM3, PRDM6_BOVINQ9NQX0, PRDM6_HUMANQ3UZD5, PRDM6_MOUSE
Q6P2A1, PRDM9_DANREQ9NQV7, PRDM9_HUMANQ96EQ9, PRDM9_MOUSE
P0C6Y7, PRDM9_RATQ9W5E0, SUV42_DROME

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-