ENZYME entry: EC 126.96.36.1991
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|[Histone H4]-lysine(20) N-methyltransferase.
|S-adenosyl-L-methionine + a [histone H4]-L-lysine(20) <=> S-adenosyl-L-homocysteine + a [histone H4]-N(6)-methyl-L-lysine(20)|
- The enzyme catalyzes the monomethylation of the L-lysine(20) residue
of histone H4 (H4K20).
- This event is usually followed by further methylation by
EC 188.8.131.522, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
- This enzyme plays a pivotal role in DNA replication.
- Activity is high during the G2 and M phases, but declines
significantly during G1 and S phases.
- Mutations in the enzyme have severe consequences, including DNA
double-strand breaks, activation of DNA damage checkpoints, defective
cell cycle progression, and reduced cell proliferation.
- Formerly EC 184.108.40.206.
|PRIAM enzyme-specific profiles||220.127.116.111|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.1681|
|IUBMB Enzyme Nomenclature||22.214.171.1241|
|MEDLINE||Find literature relating to 126.96.36.1991|
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