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ENZYME entry: EC 2.1.1.361

Accepted Name
[Histone H4]-lysine(20) N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a [histone H4]-L-lysine(20) <=> S-adenosyl-L-homocysteine + a [histone H4]-N(6)-methyl-L-lysine(20)
Comment(s)
  • The enzyme catalyzes the monomethylation of the L-lysine(20) residue of histone H4 (H4K20).
  • This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
  • This enzyme plays a pivotal role in DNA replication.
  • Activity is high during the G2 and M phases, but declines significantly during G1 and S phases.
  • Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.361
EC2PDB2.1.1.361
ExplorEnz2.1.1.361
PRIAM enzyme-specific profiles2.1.1.361
KEGG Ligand Database for Enzyme Nomenclature2.1.1.361
IUBMB Enzyme Nomenclature2.1.1.361
IntEnz2.1.1.361
MEDLINEFind literature relating to 2.1.1.361
MetaCyc2.1.1.361
Rhea expert-curated reactions2.1.1.361
UniProtKB/Swiss-Prot
Q2YDJ8, KMT5A_BOVIN;  Q9VFK6, KMT5A_DROME;  Q297V5, KMT5A_DROPS;  
Q9NQR1, KMT5A_HUMAN;  Q2YDW7, KMT5A_MOUSE;  Q0V9E9, KMT5A_XENTR;  
Q29RP8, KMT5B_BOVIN;  Q5U3H2, KMT5B_DANRE;  Q4FZB7, KMT5B_HUMAN;  
Q3U8K7, KMT5B_MOUSE;  P0C2N5, KMT5B_RAT;  Q86Y97, KMT5C_HUMAN;  
Q6Q783, KMT5C_MOUSE;  P0C2N6, KMT5C_RAT;  A0JMZ4, KMT5C_XENLA;  
Q071E0, KT5AA_DANRE;  Q08AY6, KT5AA_XENLA;  Q498E6, KT5AB_XENLA;  
Q6GP17, KT5BA_XENLA;  Q5RJX8, KT5BB_XENLA;  A6QPM3, PRDM6_BOVIN;  
Q9NQX0, PRDM6_HUMAN;  Q3UZD5, PRDM6_MOUSE;  Q6P2A1, PRDM9_DANRE;  
Q9NQV7, PRDM9_HUMAN;  Q96EQ9, PRDM9_MOUSE;  P0C6Y7, PRDM9_RAT;  
Q22795, SET1_CAEEL;  Q9W5E0, SUV42_DROME;  

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