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ENZYME

ENZYME entry: EC 2.1.1.374

Accepted Name
2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase
Reaction catalysed
2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme, found in mycobacteria, is a member of a family of heterocyclic toxin methyltransferases.
  • It is involved in defense against several antimicrobial natural compounds and drugs.
  • 4-Hydroxyquinolin-2(1H)-one, 2-heptylquinolin-4(1H)-one, 2-heptyl-3- hydroxyquinolin-4(1H)-one (the "Pseudomonas quinolone signal", PQS) and the flavonol quercetin are also O-methylated, albeit with lower activity.
  • The enzyme also N-methylates the bactericidal compound 3-methyl-1- oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5- dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile.
Cross-references
BRENDA2.1.1.374
EC2PDB2.1.1.374
ExplorEnz2.1.1.374
PRIAM enzyme-specific profiles2.1.1.374
KEGG Ligand Database for Enzyme Nomenclature2.1.1.374
IUBMB Enzyme Nomenclature2.1.1.374
IntEnz2.1.1.374
MEDLINEFind literature relating to 2.1.1.374
MetaCyc2.1.1.374
Rhea expert-curated reactions2.1.1.374
UniProtKB/Swiss-Prot
B1MCE2, HTM_MYCA9A1KG37, HTM_MYCBPA5TZU0, HTM_MYCTA
P9WKL4, HTM_MYCTOP9WKL5, HTM_MYCTU

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