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ENZYME entry: EC 2.1.1.374

Accepted Name
2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one <=> S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
Comment(s)
  • The enzyme, found in mycobacteria, is a member of a family of heterocyclic toxin methyltransferases.
  • It is involved in defense against several antimicrobial natural compounds and drugs.
  • 4-hydroxyquinolin-2(1H)-one, 2-heptylquinolin-4(1H)-one, 2-heptyl-3- hydroxyquinolin-4(1H)-one (the "Pseudomonas quinolone signal", PQS) and the flavonol quercetin are also O-methylated, albeit with lower activity.
  • The enzyme also N-methylates the bactericidal compound 3-methyl-1- oxo-2-(3-oxo-3-(pyrrolidin-1-yl)propyl)-1,5- dihydrobenzo(4,5)imidazo[1,2-a]pyridine-4-carbonitrile.
Cross-references
BRENDA2.1.1.374
EC2PDB2.1.1.374
ExplorEnz2.1.1.374
PRIAM enzyme-specific profiles2.1.1.374
KEGG Ligand Database for Enzyme Nomenclature2.1.1.374
IUBMB Enzyme Nomenclature2.1.1.374
IntEnz2.1.1.374
MEDLINEFind literature relating to 2.1.1.374
MetaCyc2.1.1.374
Rhea expert-curated reactions2.1.1.374
UniProtKB/Swiss-Prot
B1MCE2, HTM_MYCA9;  A1KG37, HTM_MYCBP;  A5TZU0, HTM_MYCTA;  
P9WKL4, HTM_MYCTO;  P9WKL5, HTM_MYCTU;  

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