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ENZYME entry: EC 2.1.1.n11

Accepted Name
Methylphosphotriester-DNA--[protein]-cysteine S-methyltransferase.
Reaction catalysed
DNA (containing Sp-methylphosphotriester) + protein L-cysteine <=> DNA (without Sp-methylphosphotriester) + protein S-methyl-L-cysteine
Cofactor(s)
Zn(2+).
Comment(s)
  • This protein is involved in the repair of Sp diastereomers of DNA methylphosphotriester lesions.
  • This enzyme catalyzes only one turnover and therefore is not strictly catalytic.
  • The enzyme from the bacterium Escherichia coli also has the activity of EC 2.1.1.63 while the enzyme from Bacillus subtilis does not.
Cross-references
UniProtKB/Swiss-Prot
P19219, ADAA_BACSU;  P06134, ADA_ECOLI;  P9WJW2, ALKA_MYCTO;  
P9WJW3, ALKA_MYCTU;  

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