| Accepted Name |
|---|
| phosphoribosylglycinamide formyltransferase 1.
|
| Alternative Name(s) |
|---|
| 2-amino-N-ribosylacetamide 5'-phosphate transformylase. |
| 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide
transformylase. |
| 5'-phosphoribosylglycinamide transformylase. |
| GAR formyltransferase. |
| GART. |
| GAR TFase. |
| GAR transformylase. |
| glycinamide ribonucleotide transformylase. |
| Reaction catalysed |
|---|
| (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide |
| Comment(s) |
|---|
- Two enzymes are known to catalyze the third step in de novo purine
biosynthesis.
- This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor,
while the other enzyme, EC 6.3.1.21, utilizes formate.
- In vertebrates this activity is catalyzed by a trifunctional enzyme
that also catalyzes the activities of EC 6.3.4.13 and EC 6.3.3.1.
|
| Cross-references |
|---|
| BRENDA | 2.1.2.2 |
| EC2PDB | 2.1.2.2 |
| ExplorEnz | 2.1.2.2 |
| PRIAM enzyme-specific profiles | 2.1.2.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.2.2 |
| IUBMB Enzyme Nomenclature | 2.1.2.2 |
| IntEnz | 2.1.2.2 |
| MEDLINE | Find literature relating to 2.1.2.2 |
| MetaCyc | 2.1.2.2 |
| Rhea expert-curated reactions | 2.1.2.2 |
| UniProtKB/Swiss-Prot |
| Q59A32, PUR2_BOVIN; | P21872, PUR2_CHICK; | Q26255, PUR2_CHITE; |
| P00967, PUR2_DROME; | P16340, PUR2_DROPS; | P22102, PUR2_HUMAN; |
| Q64737, PUR2_MOUSE; | P52422, PUR3_ARATH; | P12040, PUR3_BACSU; |
| Q54I60, PUR3_DICDI; | P08179, PUR3_ECOLI; | P43846, PUR3_HAEIN; |
| P9WHM4, PUR3_MYCTO; | P9WHM5, PUR3_MYCTU; | Q9UUK7, PUR3_SCHPO; |
| Q42805, PUR3_SOYBN; | Q5HH12, PUR3_STAAC; | P65897, PUR3_STAAM; |
| P99162, PUR3_STAAN; | Q6GI12, PUR3_STAAR; | Q6GAE1, PUR3_STAAS; |
| Q8NX89, PUR3_STAAW; | Q5HQ98, PUR3_STAEQ; | Q8CT28, PUR3_STAES; |
| P52423, PUR3_VIGUN; | P04161, PUR3_YEAST; |
|