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ENZYME

ENZYME entry: EC 2.1.2.2

Accepted Name
phosphoribosylglycinamide formyltransferase 1
Alternative Name(s)
2-amino-N-ribosylacetamide 5'-phosphate transformylase
5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase
5'-phosphoribosylglycinamide transformylase
GAR formyltransferase
GART
GAR TFase
GAR transformylase
glycinamide ribonucleotide transformylase
Reaction catalysed
(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
Comment(s)
  • Two enzymes are known to catalyze the third step in de novo purine biosynthesis.
  • This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, utilizes formate.
  • In vertebrates this activity is catalyzed by a trifunctional enzyme that also catalyzes the activities of EC 6.3.4.13 and EC 6.3.3.1.
Cross-references
BRENDA2.1.2.2
EC2PDB2.1.2.2
ExplorEnz2.1.2.2
PRIAM enzyme-specific profiles2.1.2.2
KEGG Ligand Database for Enzyme Nomenclature2.1.2.2
IUBMB Enzyme Nomenclature2.1.2.2
IntEnz2.1.2.2
MEDLINEFind literature relating to 2.1.2.2
MetaCyc2.1.2.2
Rhea expert-curated reactions2.1.2.2
UniProtKB/Swiss-Prot
Q59A32, PUR2_BOVINP21872, PUR2_CHICKQ26255, PUR2_CHITE
P00967, PUR2_DROMEP16340, PUR2_DROPSP22102, PUR2_HUMAN
Q64737, PUR2_MOUSEP52422, PUR3_ARATHP12040, PUR3_BACSU
Q54I60, PUR3_DICDIP08179, PUR3_ECOLIP43846, PUR3_HAEIN
P9WHM4, PUR3_MYCTOP9WHM5, PUR3_MYCTUQ9UUK7, PUR3_SCHPO
Q42805, PUR3_SOYBNQ5HH12, PUR3_STAACP65897, PUR3_STAAM
P99162, PUR3_STAANQ6GI12, PUR3_STAARQ6GAE1, PUR3_STAAS
Q8NX89, PUR3_STAAWQ5HQ98, PUR3_STAEQQ8CT28, PUR3_STAES
P52423, PUR3_VIGUNP04161, PUR3_YEAST

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