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ENZYME

ENZYME entry: EC 6.3.1.21

PURL: https://purl.expasy.org/enzyme/EC/6.3.1.21
Accepted Name
phosphoribosylglycinamide formyltransferase 2
Alternative Name(s)
5'-phosphoribosylglycinamide transformylase 2
GART2
GAR transformylase 2
GAR transformylase T
glycinamide ribonucleotide transformylase 2
Reaction catalysed
N(1)-(5-phospho-beta-D-ribosyl)glycinamide + formate + ATP = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
Comment(s)
  • Two enzymes are known to catalyze the third step in de novo purine biosynthesis.
  • This enzyme requires ATP and utilizes formate, which is provided by the hydrolysis of 10-formyltetrahydrofolate by EC 3.5.1.10.
  • The other enzyme, EC 2.1.2.2, utilizes 10-formyltetrahydrofolate directly.
  • Formyl phosphate is formed during catalysis as an intermediate.
  • The enzyme from the bacterium Escherichia coli can also catalyze the activity of EC 2.7.2.1.
Cross-references
BRENDA6.3.1.21
EC2PDB6.3.1.21
ExplorEnz6.3.1.21
KEGG Ligand Database for Enzyme Nomenclature6.3.1.21
IUBMB Enzyme Nomenclature6.3.1.21
MEDLINEFind literature relating to 6.3.1.21
MetaCyc6.3.1.21
Rhea expert-curated reactions6.3.1.21
UniProtKB/Swiss-Prot
Q6FAM6, PURT_ACIADA3M4Q9, PURT_ACIBTA3N1B2, PURT_ACTP2
B3GXZ2, PURT_ACTP7B0BQ46, PURT_ACTPJA0KK42, PURT_AERHH
A4SMX4, PURT_AERS4Q21SJ0, PURT_ALBFTQ0VRD0, PURT_ALCBS
Q5E4R4, PURT_ALIF1Q2IJJ5, PURT_ANADEA1K4Y1, PURT_AZOSB
C1DDZ2, PURT_AZOVDQ5LD90, PURT_BACFNQ64UB2, PURT_BACFR
P39771, PURT_BACSUQ8A9W1, PURT_BACTNA7Z0Z2, PURT_BACVZ
A1A0S3, PURT_BIFAAQ8G5B0, PURT_BIFLOQ2KUD7, PURT_BORA1
Q7WEY0, PURT_BORBRQ7W3K5, PURT_BORPAQ7W006, PURT_BORPE
A0K993, PURT_BURCHQ0BD59, PURT_BURCMQ39E61, PURT_BURL3
A3MI07, PURT_BURM7A2S4F3, PURT_BURM9Q62IF4, PURT_BURMA
A1V2C2, PURT_BURMSQ1BUU4, PURT_BURO1A3NT04, PURT_BURP0
Q3JUJ4, PURT_BURP1A3N7B6, PURT_BURP6Q63VY4, PURT_BURPS
Q2SZW6, PURT_BURTAA4JGK4, PURT_BURVGA1BHN0, PURT_CHLPD
Q8KDJ0, PURT_CHLTEQ8FMB3, PURT_COREFA4QHG1, PURT_CORGB
Q8NM23, PURT_CORGLQ4JXR6, PURT_CORJKA7MEA0, PURT_CROS8
Q1LMC7, PURT_CUPMCQ0KAH8, PURT_CUPNHQ470L8, PURT_CUPPJ
B3R259, PURT_CUPTRQ47A50, PURT_DECARA9BNI6, PURT_DELAS
Q8XCJ9, PURT_ECO57C4ZZK6, PURT_ECOBWB1XHB7, PURT_ECODH
A1AC10, PURT_ECOK1Q0TGY3, PURT_ECOL5P33221, PURT_ECOLI
Q1RAT6, PURT_ECOUTC5BGW0, PURT_EDWI9B2VJA4, PURT_ERWT9
Q2N8K3, PURT_ERYLHA6GWP9, PURT_FLAPJQ14FN7, PURT_FRAT1
A7N9C6, PURT_FRATFQ2A5V8, PURT_FRATHA0Q8N2, PURT_FRATN
Q0BP50, PURT_FRATOQ5NE84, PURT_FRATTA4IVS8, PURT_FRATW
Q39QR8, PURT_GEOMGQ7VNI4, PURT_HAEDUQ2SJZ8, PURT_HAHCH
Q18K60, PURT_HALWDA4G4X3, PURT_HERARQ0I203, PURT_HISS1
Q31DQ3, PURT_HYDCUA8ACE0, PURT_IGNH4A6SZI7, PURT_JANMA
B5XQ21, PURT_KLEV3Q04P21, PURT_LEPBJQ056L2, PURT_LEPBL
B1Y650, PURT_LEPCPQ72LY0, PURT_LEPICQ8EYF0, PURT_LEPIN
P46927, PURT_MANHAQ65VI3, PURT_MANSMA1U3I4, PURT_MARN8
C6BV99, PURT_MARSDA6UUH1, PURT_META3Q0W4L8, PURT_METAR
Q606K7, PURT_METCAQ1H1W4, PURT_METFKQ58881, PURT_METJA
A4G068, PURT_METM5A6VIB2, PURT_METM7Q6M0Z5, PURT_METMP
A6URA6, PURT_METVSB1MKI7, PURT_MYCA9A4T9D5, PURT_MYCGI
A0R2Y2, PURT_MYCS2A1TE53, PURT_MYCVPA6Q186, PURT_NITSB
Q72E56, PURT_NITV2A1VFP6, PURT_NITV4B8DJ34, PURT_NITV9
Q8YXB6, PURT_NOSS1Q30XN3, PURT_OLEA2A1TV10, PURT_PARC0
A6LHW2, PURT_PARD8Q7U3B3, PURT_PARMWQ142Q7, PURT_PARXL
Q9CLZ5, PURT_PASMUQ6D4B6, PURT_PECASC6DFT2, PURT_PECCP
A1ANT6, PURT_PELPDQ6LRI4, PURT_PHOPRA6L404, PURT_PHOV8
A1VT89, PURT_POLNAQ12FU8, PURT_POLSJA3PD91, PURT_PROM0
A2C2S8, PURT_PROM1A2CE36, PURT_PROM3A2BWY5, PURT_PROM5
Q31AM1, PURT_PROM9Q7VBB3, PURT_PROMAB4F1Q4, PURT_PROMH
Q7V3S4, PURT_PROMMQ7V179, PURT_PROMPA2BRG6, PURT_PROMS
Q46KI4, PURT_PROMTQ48LW5, PURT_PSE14B7UYK0, PURT_PSEA8
Q02RM4, PURT_PSEABQ9HXP3, PURT_PSEAEQ1I5Y3, PURT_PSEE4
Q4KHR3, PURT_PSEF5C3K1H6, PURT_PSEFSQ3KHJ9, PURT_PSEPF
B0KRH6, PURT_PSEPGQ88MW1, PURT_PSEPKB1JDF0, PURT_PSEPW
Q886V7, PURT_PSESMQ4ZWZ4, PURT_PSEU2A1SWW0, PURT_PSYIN
Q9UY67, PURT_PYRABQ8U3M7, PURT_PYRFUO58056, PURT_PYRHO
Q0SEI4, PURT_RHOJRQ981B9, PURT_SACS2A9MNE8, PURT_SALAR
Q57NB7, PURT_SALCHB5FSQ0, PURT_SALDCB4SVD3, PURT_SALNS
Q5PIA0, PURT_SALPAA9MUY8, PURT_SALPBC0Q2G8, PURT_SALPC
B5BH72, PURT_SALPKB4TYQ6, PURT_SALSVQ8Z5X3, PURT_SALTI
Q8ZNW5, PURT_SALTYA1S9F3, PURT_SHEAMA3D1A0, PURT_SHEB5
A6WK72, PURT_SHEB8Q07YK6, PURT_SHEFNQ8EBB7, PURT_SHEON
A4Y447, PURT_SHEPCA0L052, PURT_SHESAQ0HFS6, PURT_SHESM
Q0HS20, PURT_SHESRA1RMT4, PURT_SHESWB2U494, PURT_SHIB3
Q322G6, PURT_SHIBSQ32HB3, PURT_SHIDSQ0T3V7, PURT_SHIF8
Q83KS0, PURT_SHIFLQ3Z2K0, PURT_SHISSQ2NTH8, PURT_SODGM
C4XMB3, PURT_SOLM1B4SP00, PURT_STRM5B2FTB9, PURT_STRMK
A4VIT1, PURT_STUS1Q4JC46, PURT_SULACQ30UL7, PURT_SULDN
A6Q6K6, PURT_SULNBQ96Y60, PURT_SULTOQ3A5Q4, PURT_SYNC1
Q31QP9, PURT_SYNE7Q5N3J5, PURT_SYNP6A5GPT7, PURT_SYNPW
A5GX22, PURT_SYNR3Q0I600, PURT_SYNS3Q3AUF2, PURT_SYNS9
Q3AG69, PURT_SYNSCQ55336, PURT_SYNY3Q5JFN8, PURT_THEKO
Q3SKP9, PURT_THIDAB8GRA4, PURT_THISHC4LDC0, PURT_TOLAT
Q3M8Q4, PURT_TRIV2C5CP83, PURT_VARPSA7MVH5, PURT_VIBC1
Q9KSM8, PURT_VIBCHC3LLS4, PURT_VIBCMQ87Q53, PURT_VIBPA
Q8DA32, PURT_VIBVUQ7MK47, PURT_VIBVYQ8D2R3, PURT_WIGBR
Q7M8I0, PURT_WOLSUQ8PN36, PURT_XANACQ4US21, PURT_XANC8
B0RY47, PURT_XANCBQ8PBI2, PURT_XANCPQ3BW63, PURT_XANE5
Q2P047, PURT_XANOMB2SRI5, PURT_XANOPQ5GWZ8, PURT_XANOR
A1JLK9, PURT_YERE8Q1C8V8, PURT_YERPAB2K0H3, PURT_YERPB
Q7CHW4, PURT_YERPEA9R5W9, PURT_YERPGQ1CH54, PURT_YERPN
A4TKC7, PURT_YERPPQ66BW5, PURT_YERPSB1JP38, PURT_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-