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ENZYME entry: EC 6.3.1.21

Accepted Name
Phosphoribosylglycinamide formyltransferase 2.
Alternative Name(s)
5'-phosphoribosylglycinamide transformylase 2.
GAR transformylase 2.
GAR transformylase T.
GART2.
Glycinamide ribonucleotide transformylase 2.
Reaction catalysed
ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> ADP + phosphate + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
Comment(s)
  • Two enzymes are known to catalyze the third step in de novo purine biosynthesis.
  • This enzyme requires ATP and utilizes formate, which is provided by the hydrolysis of 10-formyltetrahydrofolate by EC 3.5.1.10.
  • The other enzyme, EC 2.1.2.2, utilizes 10-formyltetrahydrofolate directly.
  • Formyl phosphate is formed during catalysis as an intermediate.
  • The enzyme from the bacterium Escherichia coli can also catalyze the activity of EC 2.7.2.1.
Cross-references
BRENDA6.3.1.21
EC2PDB6.3.1.21
ExplorEnz6.3.1.21
PRIAM enzyme-specific profiles6.3.1.21
KEGG Ligand Database for Enzyme Nomenclature6.3.1.21
IUBMB Enzyme Nomenclature6.3.1.21
IntEnz6.3.1.21
MEDLINEFind literature relating to 6.3.1.21
MetaCyc6.3.1.21
Rhea expert-curated reactions6.3.1.21
UniProtKB/Swiss-Prot
A1TV10, PURT_ACIAC;  Q6FAM6, PURT_ACIAD;  A3M4Q9, PURT_ACIBT;  
A3N1B2, PURT_ACTP2;  B3GXZ2, PURT_ACTP7;  B0BQ46, PURT_ACTPJ;  
A0KK42, PURT_AERHH;  A4SMX4, PURT_AERS4;  Q0VRD0, PURT_ALCBS;  
Q5E4R4, PURT_ALIF1;  Q2IJJ5, PURT_ANADE;  A1K4Y1, PURT_AZOSB;  
C1DDZ2, PURT_AZOVD;  Q5LD90, PURT_BACFN;  Q64UB2, PURT_BACFR;  
P39771, PURT_BACSU;  Q8A9W1, PURT_BACTN;  A7Z0Z2, PURT_BACVZ;  
A1A0S3, PURT_BIFAA;  Q8G5B0, PURT_BIFLO;  Q2KUD7, PURT_BORA1;  
Q7WEY0, PURT_BORBR;  Q7W3K5, PURT_BORPA;  Q7W006, PURT_BORPE;  
Q1BUU4, PURT_BURCA;  A0K993, PURT_BURCH;  Q0BD59, PURT_BURCM;  
Q39E61, PURT_BURL3;  A3MI07, PURT_BURM7;  A2S4F3, PURT_BURM9;  
Q62IF4, PURT_BURMA;  A1V2C2, PURT_BURMS;  A3NT04, PURT_BURP0;  
Q3JUJ4, PURT_BURP1;  A3N7B6, PURT_BURP6;  Q63VY4, PURT_BURPS;  
Q2SZW6, PURT_BURTA;  A4JGK4, PURT_BURVG;  A1BHN0, PURT_CHLPD;  
Q8KDJ0, PURT_CHLTE;  Q8FMB3, PURT_COREF;  A4QHG1, PURT_CORGB;  
Q8NM23, PURT_CORGL;  Q4JXR6, PURT_CORJK;  A7MEA0, PURT_CROS8;  
Q1LMC7, PURT_CUPMC;  Q0KAH8, PURT_CUPNH;  Q470L8, PURT_CUPPJ;  
B3R259, PURT_CUPTR;  Q47A50, PURT_DECAR;  A9BNI6, PURT_DELAS;  
Q72E56, PURT_DESVH;  B8DJ34, PURT_DESVM;  A1VFP6, PURT_DESVV;  
Q8XCJ9, PURT_ECO57;  C4ZZK6, PURT_ECOBW;  B1XHB7, PURT_ECODH;  
A1AC10, PURT_ECOK1;  Q0TGY3, PURT_ECOL5;  P33221, PURT_ECOLI;  
Q1RAT6, PURT_ECOUT;  C5BGW0, PURT_EDWI9;  B2VJA4, PURT_ERWT9;  
Q2N8K3, PURT_ERYLH;  A6GWP9, PURT_FLAPJ;  Q14FN7, PURT_FRAT1;  
A7N9C6, PURT_FRATF;  Q2A5V8, PURT_FRATH;  A0Q8N2, PURT_FRATN;  
Q0BP50, PURT_FRATO;  Q5NE84, PURT_FRATT;  A4IVS8, PURT_FRATW;  
Q39QR8, PURT_GEOMG;  Q7VNI4, PURT_HAEDU;  Q0I203, PURT_HAES1;  
Q2SJZ8, PURT_HAHCH;  Q18K60, PURT_HALWD;  A4G4X3, PURT_HERAR;  
Q31DQ3, PURT_HYDCU;  A8ACE0, PURT_IGNH4;  A6SZI7, PURT_JANMA;  
B5XQ21, PURT_KLEP3;  Q04P21, PURT_LEPBJ;  Q056L2, PURT_LEPBL;  
B1Y650, PURT_LEPCP;  Q72LY0, PURT_LEPIC;  Q8EYF0, PURT_LEPIN;  
P46927, PURT_MANHA;  Q65VI3, PURT_MANSM;  A1U3I4, PURT_MARN8;  
C6BV99, PURT_MARSD;  A6UUH1, PURT_META3;  Q0W4L8, PURT_METAR;  
Q606K7, PURT_METCA;  Q1H1W4, PURT_METFK;  Q58881, PURT_METJA;  
A4G068, PURT_METM5;  A6VIB2, PURT_METM7;  Q6M0Z5, PURT_METMP;  
A6URA6, PURT_METVS;  B1MKI7, PURT_MYCA9;  A4T9D5, PURT_MYCGI;  
A0R2Y2, PURT_MYCS2;  A1TE53, PURT_MYCVP;  A6Q186, PURT_NITSB;  
Q8YXB6, PURT_NOSS1;  Q30XN3, PURT_OLEA2;  A6LHW2, PURT_PARD8;  
Q7U3B3, PURT_PARMW;  Q142Q7, PURT_PARXL;  Q9CLZ5, PURT_PASMU;  
Q6D4B6, PURT_PECAS;  C6DFT2, PURT_PECCP;  A1ANT6, PURT_PELPD;  
Q6LRI4, PURT_PHOPR;  A6L404, PURT_PHOV8;  A1VT89, PURT_POLNA;  
Q12FU8, PURT_POLSJ;  A3PD91, PURT_PROM0;  A2C2S8, PURT_PROM1;  
A2CE36, PURT_PROM3;  A2BWY5, PURT_PROM5;  Q31AM1, PURT_PROM9;  
Q7VBB3, PURT_PROMA;  B4F1Q4, PURT_PROMH;  Q7V3S4, PURT_PROMM;  
Q7V179, PURT_PROMP;  A2BRG6, PURT_PROMS;  Q46KI4, PURT_PROMT;  
Q48LW5, PURT_PSE14;  B7UYK0, PURT_PSEA8;  Q02RM4, PURT_PSEAB;  
Q9HXP3, PURT_PSEAE;  Q1I5Y3, PURT_PSEE4;  Q4KHR3, PURT_PSEF5;  
C3K1H6, PURT_PSEFS;  Q3KHJ9, PURT_PSEPF;  B0KRH6, PURT_PSEPG;  
Q88MW1, PURT_PSEPK;  B1JDF0, PURT_PSEPW;  Q886V7, PURT_PSESM;  
Q4ZWZ4, PURT_PSEU2;  A4VIT1, PURT_PSEU5;  A1SWW0, PURT_PSYIN;  
Q9UY67, PURT_PYRAB;  Q8U3M7, PURT_PYRFU;  O58056, PURT_PYRHO;  
Q21SJ0, PURT_RHOFT;  Q0SEI4, PURT_RHOJR;  Q981B9, PURT_SACS2;  
A9MNE8, PURT_SALAR;  Q57NB7, PURT_SALCH;  B5FSQ0, PURT_SALDC;  
B4SVD3, PURT_SALNS;  Q5PIA0, PURT_SALPA;  A9MUY8, PURT_SALPB;  
C0Q2G8, PURT_SALPC;  B5BH72, PURT_SALPK;  B4TYQ6, PURT_SALSV;  
Q8Z5X3, PURT_SALTI;  Q8ZNW5, PURT_SALTY;  A1S9F3, PURT_SHEAM;  
A3D1A0, PURT_SHEB5;  A6WK72, PURT_SHEB8;  Q07YK6, PURT_SHEFN;  
Q8EBB7, PURT_SHEON;  A4Y447, PURT_SHEPC;  A0L052, PURT_SHESA;  
Q0HFS6, PURT_SHESM;  Q0HS20, PURT_SHESR;  A1RMT4, PURT_SHESW;  
B2U494, PURT_SHIB3;  Q322G6, PURT_SHIBS;  Q32HB3, PURT_SHIDS;  
Q0T3V7, PURT_SHIF8;  Q83KS0, PURT_SHIFL;  Q3Z2K0, PURT_SHISS;  
Q2NTH8, PURT_SODGM;  C4XMB3, PURT_SOLM1;  B4SP00, PURT_STRM5;  
B2FTB9, PURT_STRMK;  Q4JC46, PURT_SULAC;  Q30UL7, PURT_SULDN;  
A6Q6K6, PURT_SULNB;  Q96Y60, PURT_SULTO;  Q3A5Q4, PURT_SYNC1;  
Q31QP9, PURT_SYNE7;  Q5N3J5, PURT_SYNP6;  A5GPT7, PURT_SYNPW;  
A5GX22, PURT_SYNR3;  Q0I600, PURT_SYNS3;  Q3AUF2, PURT_SYNS9;  
Q3AG69, PURT_SYNSC;  Q55336, PURT_SYNY3;  Q5JFN8, PURT_THEKO;  
Q3SKP9, PURT_THIDA;  B8GRA4, PURT_THISH;  C4LDC0, PURT_TOLAT;  
Q3M8Q4, PURT_TRIV2;  C5CP83, PURT_VARPS;  A7MVH5, PURT_VIBCB;  
Q9KSM8, PURT_VIBCH;  C3LLS4, PURT_VIBCM;  Q87Q53, PURT_VIBPA;  
Q8DA32, PURT_VIBVU;  Q7MK47, PURT_VIBVY;  Q8D2R3, PURT_WIGBR;  
Q7M8I0, PURT_WOLSU;  Q8PN36, PURT_XANAC;  Q3BW63, PURT_XANC5;  
Q4US21, PURT_XANC8;  B0RY47, PURT_XANCB;  Q8PBI2, PURT_XANCP;  
Q2P047, PURT_XANOM;  B2SRI5, PURT_XANOP;  Q5GWZ8, PURT_XANOR;  
A1JLK9, PURT_YERE8;  Q1C8V8, PURT_YERPA;  B2K0H3, PURT_YERPB;  
Q7CHW4, PURT_YERPE;  A9R5W9, PURT_YERPG;  Q1CH54, PURT_YERPN;  
A4TKC7, PURT_YERPP;  Q66BW5, PURT_YERPS;  B1JP38, PURT_YERPY;  

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