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ENZYME entry: EC 2.1.3.10

Accepted Name
Malonyl-S-ACP:biotin-protein carboxyltransferase.
Reaction catalysed
A malonyl-[acyl-carrier protein] + a biotinyl-[protein] <=> an acetyl-[acyl-carrier protein] + a carboxybiotinyl-[protein]
Comment(s)
  • Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC 7.2.4.4.
  • The carboxy group is transferred from malonate to the prosthetic group of the biotin protein (MadF) with retention of configuration.
  • Similar to EC 4.1.1.87, which forms part of the biotin-independent EC 4.1.1.88, this enzyme also follows on from EC 2.3.1.187, and results in the regeneration of the acetyl-[acyl-carrier protein].
Cross-references
PROSITEPDOC50980
BRENDA2.1.3.10
EC2PDB2.1.3.10
ExplorEnz2.1.3.10
PRIAM enzyme-specific profiles2.1.3.10
KEGG Ligand Database for Enzyme Nomenclature2.1.3.10
IUBMB Enzyme Nomenclature2.1.3.10
IntEnz2.1.3.10
MEDLINEFind literature relating to 2.1.3.10
MetaCyc2.1.3.10
Rhea expert-curated reactions2.1.3.10
UniProtKB/Swiss-Prot
O06926, MADC_MALRU;  O06927, MADD_MALRU;  

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