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ENZYME entry: EC 2.2.1.11

Accepted Name
6-deoxy-5-ketofructose 1-phosphate synthase.
Alternative Name(s)
DKFP synthase.
Reaction catalysed
  • beta-D-fructose 1,6-bisphosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate
  • beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde
Comment(s)
  • The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme can also catalyze the reaction of EC 4.1.2.13.
Cross-references
BRENDA2.2.1.11
EC2PDB2.2.1.11
ExplorEnz2.2.1.11
PRIAM enzyme-specific profiles2.2.1.11
KEGG Ligand Database for Enzyme Nomenclature2.2.1.11
IUBMB Enzyme Nomenclature2.2.1.11
IntEnz2.2.1.11
MEDLINEFind literature relating to 2.2.1.11
MetaCyc2.2.1.11
Rhea expert-curated reactions2.2.1.11
UniProtKB/Swiss-Prot
Q58980, DKFP_METJA

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