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ENZYME entry: EC 4.1.2.13

Accepted Name
fructose-bisphosphate aldolase
Alternative Name(s)
aldolase
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase
fructose-1,6-bisphosphate triosephosphate-lyase
Reaction catalysed
beta-D-fructose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
Comment(s)
  • Also acts on (3S,4R)-ketose 1-phosphates.
  • The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
  • Formerly EC 4.1.2.7.
Cross-references
BRENDA4.1.2.13
EC2PDB4.1.2.13
ExplorEnz4.1.2.13
PRIAM enzyme-specific profiles4.1.2.13
KEGG Ligand Database for Enzyme Nomenclature4.1.2.13
IUBMB Enzyme Nomenclature4.1.2.13
IntEnz4.1.2.13
MEDLINEFind literature relating to 4.1.2.13
MetaCyc4.1.2.13
Rhea expert-curated reactions4.1.2.13
UniProtKB/Swiss-Prot
Q4KMC8, ALDCA_DANREQ8JH70, ALDCB_DANREP86980, ALDOA_GADMO
P04075, ALDOA_HUMANP05064, ALDOA_MOUSEA5A6I5, ALDOA_PANTR
Q5NVR5, ALDOA_PONABP00883, ALDOA_RABITP05065, ALDOA_RAT
B5DGM7, ALDOA_SALSAP86979, ALDOA_THUALQ3T0S5, ALDOB_BOVIN
P07341, ALDOB_CHICKQ8JH71, ALDOB_DANREP05062, ALDOB_HUMAN
Q91Y97, ALDOB_MOUSEQ5RFA6, ALDOB_PONABP79226, ALDOB_RABIT
P00884, ALDOB_RATP52210, ALDOB_SHEEPP53447, ALDOB_SPAAU
P53448, ALDOC_CARAUP53449, ALDOC_CHICKP09972, ALDOC_HUMAN
Q9GKW3, ALDOC_MACFAP05063, ALDOC_MOUSEQ5R1X4, ALDOC_PANTR
P09117, ALDOC_RATQ9YG90, ALF1_AERPEP54216, ALF1_CAEEL
P27995, ALF1_CERSPQ9PKH8, ALF1_CHLMUQ9Z8Q7, ALF1_CHLPN
O84217, ALF1_CHLTRQ97TN4, ALF1_CLOABA6LXU8, ALF1_CLOB8
Q59100, ALF1_CUPNHP0A992, ALF1_ECOL6P0A991, ALF1_ECOLI
Q8RGH3, ALF1_FUSNNB0R3Y0, ALF1_HALS3Q9HRI2, ALF1_HALSA
P53445, ALF1_LETCAQ8ELI2, ALF1_OCEIHQ96UH7, ALF1_PARBA
P46256, ALF1_PEAB2RLG9, ALF1_PORG3P60053, ALF1_PORGI
Q9V2I6, ALF1_PYRABP58314, ALF1_PYRFUO57840, ALF1_PYRHO
A7X6Y6, ALF1_STAA1A6U4Y6, ALF1_STAA2Q2FDQ4, ALF1_STAA3
Q2FV17, ALF1_STAA8A5IW31, ALF1_STAA9Q2YWF3, ALF1_STAAB
Q5HCU6, ALF1_STAACA6QK93, ALF1_STAAEP67472, ALF1_STAAM
P99117, ALF1_STAANQ6GDJ7, ALF1_STAARQ6G670, ALF1_STAAS
A8Z3K5, ALF1_STAATQ8NUM5, ALF1_STAAWQ07159, ALF1_STACT
Q5HL21, ALF1_STAEQQ8CMY5, ALF1_STAESQ4L9B6, ALF1_STAHJ
P74309, ALF1_SYNY3Q8J308, ALF1_THEKOP58315, ALF1_THETK
Q73QV3, ALF1_TREDEQ8PHB5, ALF1_XANACQ8P5Z7, ALF1_XANCP
Q9PF52, ALF1_XYLFAQ87AI0, ALF1_XYLFTP46563, ALF2_CAEEL
P29271, ALF2_CERSPQ59101, ALF2_CUPNHP53446, ALF2_LETCA
Q8J0N6, ALF2_PARBAP46257, ALF2_PEAP49577, ALF2_PLABA
P50923, ALF2_RHOCAQ5HE75, ALF2_STAACP67477, ALF2_STAAM
P99075, ALF2_STAANQ6GEV0, ALF2_STAARQ6G7I5, ALF2_STAAS
P67478, ALF2_STAAWQ5HM97, ALF2_STAEQQ8CNI3, ALF2_STAES
Q55664, ALF2_SYNY3P17784, ALFC1_ORYSJQ01516, ALFC1_PEA
Q10A30, ALFC2_ORYSJQ01517, ALFC2_PEAQ5N725, ALFC3_ORYSJ
F4KGQ0, ALFC4_ARATHO65581, ALFC5_ARATHQ9SJQ9, ALFC6_ARATH
P22197, ALFC7_ARATHQ9LF98, ALFC8_ARATHQ42690, ALFC_CHLRE
P84722, ALFC_PINSTP16096, ALFC_SPIOLQ9SJU4, ALFP1_ARATH
Q944G9, ALFP2_ARATHQ9ZU52, ALFP3_ARATHQ40677, ALFP_ORYSJ
P83155, ALF_ANASLQ9HGY9, ALF_ASPORP13243, ALF_BACSU
O51401, ALF_BORBUP57526, ALF_BUCAIQ8K9B2, ALF_BUCAP
Q89AB6, ALF_BUCBPQ0PAS0, ALF_CAMJEA1VYV7, ALF_CAMJJ
Q9URB4, ALF_CANALO65735, ALF_CICARP0CJ44, ALF_COCIM
P19537, ALF_CORGLQ86A67, ALF_DICDIP07764, ALF_DROME
Q9GP32, ALF_ECHMUP0AB72, ALF_ECO57P0AB71, ALF_ECOLI
O52402, ALF_EDWI9Q8SSM8, ALF_ENCCUP94453, ALF_GEOSE
A8B2U2, ALF_GIAICP44429, ALF_HAEIND4GYE0, ALF_HALVD
Q9ZMQ6, ALF_HELPJP56109, ALF_HELPYQ9C2U0, ALF_KLULA
P91759, ALF_LYMSTP08440, ALF_MAIZEP67476, ALF_MYCBO
P47269, ALF_MYCGEO69600, ALF_MYCLEP75089, ALF_MYCPN
P9WQA2, ALF_MYCTOP9WQA3, ALF_MYCTUP53444, ALF_NEUCR
Q9XDP3, ALF_NOSCOQ8YNK2, ALF_NOSS1Q7KQL9, ALF_PLAF7
P14223, ALF_PLAFAQ27744, ALF_PLAFKQ9I5Y1, ALF_PSEAE
P58336, ALF_RHIMEP53442, ALF_SCHMAP36580, ALF_SCHPO
P0AB73, ALF_SHIFLP56888, ALF_SINMWP29356, ALF_SPIOL
Q9X8R6, ALF_STRCOQ9ZEM7, ALF_STRGBP68905, ALF_STRP1
P0CZ58, ALF_STRP3Q5XA12, ALF_STRP6P68906, ALF_STRP8
P0A4S1, ALF_STRPNP0CZ59, ALF_STRPQP0A4S2, ALF_STRR6
O87796, ALF_STUSTQ703I2, ALF_THECAO83668, ALF_TREPA
P07752, ALF_TRYBBQ9PPP3, ALF_UREPAQ56815, ALF_XANFL
P14540, ALF_YEASTQ58980, DKFP_METJAA0RV30, FBPAP_CENSY
A8A9E4, FBPAP_IGNH4Q57747, FBPAP_METJAA4YIZ5, FBPAP_METS5
D9PUH5, FBPAP_METTMQ2RG86, FBPAP_MOOTAB1YAL1, FBPAP_PYRNV
F9VMT6, FBPAP_SULTOQ8NKR9, FBPAP_THEKOB6YTP6, FBPAP_THEON
Q72K02, FBPAP_THET2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
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