Home  |  Contact

ENZYME entry: EC

Accepted Name
Mycocerosate synthase.
Reaction catalysed
  • A long-chain acyl-[mycocerosic acid synthase] + 3 methylmalonyl-CoA + 6 NADPH <=> a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CoA + 3 CO(2) + 6 NADP(+) + 3 H(2)O
  • A long-chain acyl-[mycocerosate synthase] + 4 methylmalonyl-CoA + 8 NADPH <=> a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CoA + 4 CO(2) + 8 NADP(+) + 4 H(2)O
  • The enzyme, characterized from mycobacteria, is loaded with a long- chain acyl moiety by EC and elongates it by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8- tetramethyloctacosanoate (C(32)-mycocerosate).
  • Since the enzyme lacks a thioesterase domain, the product remains bound and requires additional enzyme(s) for removal.
  • Even though the enzyme can accept C(6) to C(20) substrates in vitro, it prefers to act on C(14)-C(20) substrates in vivo.
PRIAM enzyme-specific profiles2.3.1.111
KEGG Ligand Database for Enzyme Nomenclature2.3.1.111
IUBMB Enzyme Nomenclature2.3.1.111
MEDLINEFind literature relating to
Rhea expert-curated reactions2.3.1.111

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-