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ENZYME entry: EC 6.2.1.49

Accepted Name
Long-chain fatty acid adenylyltransferase FadD28.
Reaction catalysed
ATP + a long-chain fatty acid + holo-[mycocerosate synthase] <=> AMP + diphosphate + a long-chain acyl-[mycocerosate synthase]
Comment(s)
  • The enzyme, found in certain mycobacteria, activates long-chain fatty acids by adenylation and transfers them to EC 2.3.1.111.
  • The enzyme participates in the biosynthesis of the virulent lipids dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL).
  • Formerly EC 2.7.7.95.
Cross-references
BRENDA6.2.1.49
EC2PDB6.2.1.49
ExplorEnz6.2.1.49
PRIAM enzyme-specific profiles6.2.1.49
KEGG Ligand Database for Enzyme Nomenclature6.2.1.49
IUBMB Enzyme Nomenclature6.2.1.49
IntEnz6.2.1.49
MEDLINEFind literature relating to 6.2.1.49
MetaCyc6.2.1.49
Rhea expert-curated reactions6.2.1.49
UniProtKB/Swiss-Prot
Q02278, FAA28_MYCBO;  B2HIM0, FAA28_MYCMM;  P9WQ58, FAA28_MYCTO;  
P9WQ59, FAA28_MYCTU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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