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ENZYME entry: EC 2.3.1.156

Accepted Name
Phloroisovalerophenone synthase.
Alternative Name(s)
3-methyl-1-(trihydroxyphenyl)butan-1-one synthase.
Valerophenone synthase.
Reaction catalysed
Isovaleryl-CoA + 3 malonyl-CoA <=> 4 CoA + 3 CO(2) + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
Comment(s)
  • Closely related to EC 2.3.1.74.
  • The product, 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one, is phloroisovalerophenone.
  • Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone.
  • The products are intermediates in the biosynthesis of the bitter (alpha) acids in hops (Humulus lupulus).
Cross-references
PROSITEPDOC00403
BRENDA2.3.1.156
EC2PDB2.3.1.156
ExplorEnz2.3.1.156
PRIAM enzyme-specific profiles2.3.1.156
KEGG Ligand Database for Enzyme Nomenclature2.3.1.156
IUBMB Enzyme Nomenclature2.3.1.156
IntEnz2.3.1.156
MEDLINEFind literature relating to 2.3.1.156
MetaCyc2.3.1.156
UniProtKB/Swiss-Prot
O80400, VPS_HUMLU;  Q9SLX9, VPS_PSINU;  

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