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ENZYME entry: EC 2.3.1.156

Accepted Name
phloroisovalerophenone synthase.
Alternative Name(s)
3-methyl-1-(trihydroxyphenyl)butan-1-one synthase.
acylphloroglucinol synthase.
valerophenone synthase.
Reaction catalysed
  • 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone
  • 2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisobutanophenone
Comment(s)
  • Closely related to EC 2.3.1.74.
  • Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone.
  • The products are intermediates in the biosynthesis of the bitter acids in hops (Humulus lupulus) and glucosides in strawberry (Fragaria X ananassa).
  • It is also able to generate naringenin chalcone from 4-coumaroyl-CoA.
Cross-references
BRENDA2.3.1.156
EC2PDB2.3.1.156
ExplorEnz2.3.1.156
PRIAM enzyme-specific profiles2.3.1.156
KEGG Ligand Database for Enzyme Nomenclature2.3.1.156
IUBMB Enzyme Nomenclature2.3.1.156
IntEnz2.3.1.156
MEDLINEFind literature relating to 2.3.1.156
MetaCyc2.3.1.156
Rhea expert-curated reactions2.3.1.156
UniProtKB/Swiss-Prot
Q9FEY5, CHSH1_HUMLU;  O80400, VPS_HUMLU;  Q9SLX9, VPS_PSINU;  

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