ENZYME entry: EC 2.3.1.161
Accepted Name |
Lovastatin nonaketide synthase.
|
Reaction catalysed |
9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] <=> dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O |
Comment(s) |
- This fungal enzyme system comprises a multi-functional polyketide
synthase (PKS) and an enoyl reductase.
- The PKS catalyzes many of the chain building reactions of
EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder
reaction, while the reductase is responsible for three enoyl
reductions that are necessary for dihydromonacolin L acid production.
|
Cross-references |
PROSITE | PDOC00529 |
BRENDA | 2.3.1.161 |
EC2PDB | 2.3.1.161 |
ExplorEnz | 2.3.1.161 |
PRIAM enzyme-specific profiles | 2.3.1.161 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.161 |
IUBMB Enzyme Nomenclature | 2.3.1.161 |
IntEnz | 2.3.1.161 |
MEDLINE | Find literature relating to 2.3.1.161 |
MetaCyc | 2.3.1.161 |
UniProtKB/Swiss-Prot |
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ENZYME /
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