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ENZYME entry: EC 2.3.1.161

Accepted Name
Lovastatin nonaketide synthase.
Reaction catalysed
9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] <=> dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O
Comment(s)
  • This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase.
  • The PKS catalyzes many of the chain building reactions of EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.
Cross-references
PROSITEPDOC00529
BRENDA2.3.1.161
EC2PDB2.3.1.161
ExplorEnz2.3.1.161
PRIAM enzyme-specific profiles2.3.1.161
KEGG Ligand Database for Enzyme Nomenclature2.3.1.161
IUBMB Enzyme Nomenclature2.3.1.161
IntEnz2.3.1.161
MEDLINEFind literature relating to 2.3.1.161
MetaCyc2.3.1.161
UniProtKB/Swiss-Prot
Q9Y8A5, LNKS_ASPTE;  Q0C8M3, LNKS_ASPTN;  Q9Y7D0, LOVC_ASPTE;  
Q3S2T9, MOKA_MONPI;  

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