ENZYME entry: EC 2.3.1.161

Accepted Name

Lovastatin nonaketide synthase.

Reaction catalysed

9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] <=> dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O

Comment(s)

This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase.
The PKS catalyzes many of the chain building reactions of EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

2.3.1.161

KEGG Ligand Database for Enzyme Nomenclature

2.3.1.161

IUBMB Enzyme Nomenclature

2.3.1.161

IntEnz

2.3.1.161

MEDLINE

Find literature relating to 2.3.1.161

MetaCyc

2.3.1.161

UniProtKB/Swiss-Prot

Q9Y8A5, LNKS_ASPTE;	Q0C8M3, LNKS_ASPTN;	Q9Y7D0, LOVC_ASPTE;
Q3S2T9, MOKA_MONPI;

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-