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ENZYME

ENZYME entry: EC 2.3.1.176

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.176
Accepted Name
propanoyl-CoA C-acyltransferase
Alternative Name(s)
3-oxopristanoyl-CoA hydrolase
3-oxopristanoyl-CoA thiolase
peroxisomal thiolase 2
propionyl-CoA C(2)-trimethyltridecanoyltransferase
PTE-2
SCPchi
SCP-X
sterol carrier protein-chi
sterol carrier protein-X
Reaction catalysed
choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA
Comment(s)
  • Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives.
  • Catalyzes the penultimate step in the formation of bile acids.
  • The bile acid moiety is transferred from the acyl-CoA thioester (RCO- SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65.
  • Formerly EC 2.3.1.154.
Cross-references
BRENDA2.3.1.176
EC2PDB2.3.1.176
ExplorEnz2.3.1.176
KEGG Ligand Database for Enzyme Nomenclature2.3.1.176
IUBMB Enzyme Nomenclature2.3.1.176
MEDLINEFind literature relating to 2.3.1.176
MetaCyc2.3.1.176
Rhea expert-curated reactions2.3.1.176
UniProtKB/Swiss-Prot
G5EDP2, NLTP2_CAEELP07857, SCP2_BOVINQ07598, SCP2_CHICK
P22307, SCP2_HUMANP32020, SCP2_MOUSEO62742, SCP2_RABIT
P11915, SCP2_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-